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FORMATION AND CHARACTERIZATION OF SUCCINOYL CHITOSAN PARTICLES LOADED WITH WARNERIN

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Shagdarova B. T., Ilyina A. V., Lopatin S. A., Korobov V. P., Lemkina L. M., Varlamov V. P.

Progress on Chemistry and Application of Chitin and its Derivatives

2015

vol. 20

246-253

This study aims to obtain nanoparticles based on succinoyl chitosan loaded with Warnerin (War-SCNPs), low molecular weight cationic peptide. The nanoparticles of succinoyl chitosan (SCNPs) were prepared by salt coacervation method, and Warnerin loading efficiency on SCNPs was reached 75% in the optimum conditions, particularly, ration (SCNPs : peptide) was equal to (1.75 : 1, μg / ml ). Formed War-SCNPs were stable, had a weak electric charge from (-4.4) to (-14,6) mV. Determining of SCNPs size showed that a main fraction of SCNPs had the size of 160 nm, and after the peptide sorption War-SCNPs size increased up to 330 nm. The experimental data of this study will likely impact War-SCNPs use as therapeutic delivery systems of the peptide to be administered parenteral.

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1 Progress on Chemistry and Application of Chitin and its Derivatives

1 2015

1 Ilyina A. V.

1 Korobov V. P.

1 Lemkina L. M.

1 Lopatin S. A.

1 Shagdarova B. T.

1 Varlamov V. P.

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FORMATION AND CHARACTERIZATION OF SUCCINOYL CHITOSAN PARTICLES LOADED WITH WARNERIN