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Contribution of Peripheral and Central Fatigue in Different Conditions (Gender and Time of Day Differences)

100%

Nourshahi M., Alirezaei F., Bahrpeyma F.

Journal of Human Kinetics

2010

vol. 25

27-34

The aim of the present study was to examine the rate of central and peripheral contributions in circadian rhythms and gender differences after exhausted maximal exercise. From 36 volunteers, 12 healthy male and female subjects who had H-reflex (It is elicited by electrical stimulation and it has been suggested to be one of mechanisms that could cause central fatigue) were selected (mean age of 23.5±1.37 years, height of 166.83±5.11cm, weight of 59.8±9.15 kg, VO2max of 33.14±4.71 ml. kg-1. min-1in male subjects and mean age of 23±6.32 years, height of 165.17±2.48 cm, weight of 56±2.09 kg and VO2max of 29.05±2.89 ml. kg-1. min-1 in female subjects) and took part in this investigation. Central (MVC, latency of H-reflex, amplitude of H-reflex and ratio of H-reflex to M-wave) and peripheral properties of fatigue (blood lactate and M-wave) were recorded before and after an exhausted maximal exercise at two different times of day: 9 am and 6 pm which is separated by a week. Significant differences were found in HR, blood lactate and latency of H-reflex before and after exercise. However differences between male and female in MVC, amplitude of H-reflex, ratio of H-reflex to M-wave and M-wave was significant. With induced -exercise, central and peripheral fatigue was higher in men in the morning and in women in the afternoon., thus our results recommended designing suitable exercise programs for men and women in the afternoon and morning, respectively. However, further studies are needed to confirm these results, especially in recommending using transcranial magnetic stimulation.

Mechanizm zegara biologicznego. Nagroda Nobla 2017 w dziedzinie fizjologii lub medycyny

63%

Giebultowicz J.

Kosmos

2018

vol. 67

issue 2

245-249

Since 1901, the Nobel Prize has been awarded to scientists who have made the most important discoveries for the benefit of humanity. The 2017 Nobel Prize in Physiology or Medicine was awarded jointly to Jeffrey C. Hall, Michael Rosbash and Michael W. Young “for their discoveries of molecular mechanisms controlling the circadian rhythm.” It may be surprising to learn that those three scientists dedicated their entire careers to research on the fruit fly, Drosophila melanogaster. However, as their studies progressed, it became increasingly clear that the mechanism of the biological clock that they discovered in Drosophila is very similar to a timekeeping mechanism present in mammals, including humans. Through interdisciplinary work between scientists performing basic research on model organisms and medical doctors, we have learned over time that daily rhythms support human health while disruption of these rhythms is associated with a range of pathological disorders such as cardiovascular problems, metabolic, neurological, and many other diseases. This short review highlights critical milestones on the way to understanding biological clocks, focusing on the roles played by the three Nobel Prize winners.

Od roku 1901 Nagroda Nobla jest przyznawana naukowcom za najważniejsze odkrycia służące dobru ludzkosci. Nagrodę Nobla w dziedzinie fizjologii lub medycyny w 2017 roku otrzymali trzej amerykańscy uczeni Jeffrey C. Hall, Michael Rosbash i Michael W. Young "za odkrycie mechanizmu molekularnego, który kontroluje rytmy okołodobowe". Może się to wydać zaskakujące, ale ci trzej nobliści poświęcili swoje kariery naukowe badaniom nad muszką owocową, Drosophila melanogaster. Jednak w miarę postępu ich badań stawało się coraz bardziej oczywiste, że mechanizm zegara biologicznego, odkryty u muszki Drosophila, jest bardzo podobny do zegara, który posiadają ssaki, łącznie z człowiekiem. Interdyscyplinarna współpraca między naukowcami prowadzącymi badania podstawowe na organizmach modelowych i lekarzami prowadzącymi badania kliniczne ujawniła istotną rolę rytmów dobowych w utrzymaniu zdrowia człowieka. Dlugotrwałe zakłócenie tych rytmów stanowi czynnik ryzyka wielu patologii, takich jak choroby serca, cukrzyca, otyłość czy choroby układu nerwowego. Artykuł krótko podsumowuje odkrycia, stanowiące kamienie milowe na drodze poznania mechanizmu zegara biologicznego, ze szczególnym uwzględnieniem roli trzech noblistów 2017 w tym procesie.

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Contribution of Peripheral and Central Fatigue in Different Conditions (Gender and Time of Day Differences)

Mechanizm zegara biologicznego. Nagroda Nobla 2017 w dziedzinie fizjologii lub medycyny