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The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line

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Łazarenkow A., Michalska M., Gorąca A., Mirowski M., Nawrot-Modranka J., Piechota-Polanczyk A.
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2013
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vol. 60
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issue 2
259-262
EN
Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).
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Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

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Michalska M., Pająk W., Kołodziejska J., Łazarenkow A., Nawrot-Modranka J.
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2008
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vol. 55
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issue 3
613-617
EN
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
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