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Tissue-specific effect of refeeding after short- and long-term caloric restriction on malic enzyme gene expression in rat tissues.

100%

Stelmanska E., Korczynska J., Swierczynski J.

vol. 51

issue 3

805-814

Restricting food intake to a level below that consumed voluntarily (85%, 70% and 50% of the ad libitum energy intake for 3 or 30 days) and re-feeding ad libitum for 48 h results in an increase of malic enzyme (ME) gene expression in rat white adipose tissue. The increase of ME gene expression was much more pronounced in rats maintained on restricted diet for 30 days than for 3 days. The changes in ME gene expression resembled the changes in the content of SREBP-1 in white adipose tissue. A similar increase of serum insulin concentration was observed in all groups at different degrees of caloric restriction and refed ad libitum for 48 h. Caloric restriction and refeeding caused on increase of ME activity also in brown adipose tissue (BAT) and liver. However, in liver a significant increase of ME activity was found only in rats maintained on the restricted diet for 30 days. No significant changes after caloric restriction and refeeding were found in heart, skeletal muscle, kidney cortex, and brain. These data indicate that the increase of ME gene expression after caloric restriction/refeeding occurs only in lipogenic tissues. Thus, one can conclude that caloric restriction/refeeding increases the enzymatic capacity for fatty acid biosynthesis.

Caloric Restriction Diet (CR diet) or Mediterranean Diet (MD) - Which is the Best Choice for Former Athletes?

100%

Czerwińska M., Hołowko J., Maciejewska D., Wysokiński P., Ficek K., Wilk P., Stachowska E.

Central European Journal of Sport Sciences and Medicine

2016

vol. 13

issue 1

23-35

Overweight or obesity which often develop in athletes who end their careers is one of the most important issues of the world of sport. During aging, an increase in the amount of intra-abdominal fat is observed; this fat increases the risk of such metabolic disease as diabetes or hypertension. The participants of the study were 94 males. The people were randomly assigned to one of 2 groups: group 1 – people using the diet based on calorie restriction CRON (n = 32), and group 2 – those who followed the recommendations of the Mediterranean diet (n = 34). The patients who at the check-up declared not following any diet were assigned to the control group (n = 28). A change in parameters was observed in each of the sub-groups after the intervention. The most significant changes were observed in the sub-group which lost >2.6 kg. Both the diet based on mild calorie restriction and the Mediterranean diet had positive effect on the change of the former athlete’s body parameters after the 6-week long dietary intervention. Both diets which were being tested changed the body composition of the athletes who ended their careers in a similar way.

Naturalne i syntetyczne modulatory aktywności sirtuin

63%

Wiercińska M., Rosołowska-Huszcz D.

Kosmos

2017

vol. 66

issue 3

365-377

Sirtuiny należą do rodziny deacetylaz histonów zależnych od NAD. Ich substratami jest wiele enzymów i czynników transkrypcyjnych, a kontrolując ich aktywność sirtuiny uczestniczą w utrzymaniu homeostazy ustroju. Sirtuiny mogą ograniczać rozwój schorzeń związanych z wiekiem, w tym nowotworów. Ich aktywność modulowana jest przez wiele czynników żywieniowych. Restrykcja kaloryczna oraz niektóre aminokwasy przyczyniają się do wzrostu aktywności sirtuin. Natomiast nadmierne spożycie tłuszczu i węglowodanów hamuje ich aktywność. Naturalnymi aktywatorami sirtuin, występującymi w żywności są niektóre związki z grupy flawonoli, katechin, alkaloidów oraz izoflawonów. Aktualnie trwają prace nad znalezieniem nowych syntetycznych aktywatorów sirtuin. Ze względu na potencjalny udział niektórych sirtuin w patogenezie chorób neurodegeneracyjnych poszukuje się inhibitorów tych enzymów.

Sirtuins belong to the family of NAD-dependent histone deacetylases. Sirtuin substrates include a great number of enzymes and transcription factors. In this way sirtuins regulate homeostasis of the whole organism. Sirtuins can limit the development of age-related diseases, including cancers. Their activity is modulated by many nutritional factors. Caloric restriction and some amino acids contribute to sirtuins stimulation. Excessive intake of fat and carbohydrates inhibits their activity. Daily diet includes natural sirtuin activators such as flavanoles, catechins, alcaloids and isoflavonoids. Currently, new synthetic activators of sirtuins are under investigations. In view of possible involvement of some sirtuins in pathogenesis of neurodegenerative diseases, search for inhibitors of this class of enzymes is of particular importance.

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1 Acta Biochimica Polonica

1 Central European Journal of Sport Sciences and Medicine

1 Kosmos

1 2017

1 2016

1 2004

1 Czerwińska M.

1 Ficek K.

1 Hołowko J.

1 Korczynska J.

1 Maciejewska D.

1 Rosołowska-Huszcz D.

1 Stachowska E.

1 Stelmanska E.

1 Swierczynski J.

1 Wiercińska M.

1 Wilk P.

1 Wysokiński P.

Search results

Tissue-specific effect of refeeding after short- and long-term caloric restriction on malic enzyme gene expression in rat tissues.

Caloric Restriction Diet (CR diet) or Mediterranean Diet (MD) - Which is the Best Choice for Former Athletes?

Naturalne i syntetyczne modulatory aktywności sirtuin