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Filling of Tissue Defects in the Hand With A Pediculed Osteocutaneous Groin Flap

100%
Jabłecki J., Kaczmarzyk L., Domanasiewicz A., Paruzel M.
Polish Journal of Surgery
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2009
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vol. 81
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issue 5
230-235
EN
The aim of the study was to evaluate the efficacy of pedicled osteocutaneous groin flaps in treatment of tissue defects of the hand.Material and methods. Twelve pedicled osteocutaneous groin flaps were used to fill bone defects of the hand in the same amount of patients (10 males and 2 females) aged 20-53 years (mean 33.4 years, SD 12 years). The defects affected metacarpal bones and wrist in 2 cases, metacarpus alone in 3 cases, fingers - in 4 (total amputations of 3 or 4 fingers), and thumb in 3 (total amputations). The osseous fragment measured from 6-18 ccm (mean 12.4 ccm). The osteosynthesis was performed using K-wires (10 patients) or AO headless cortical screw (2 patients). The flaps were detached gradually starting from postoperative day 18 with the final detachment performed on p.o. day 24-33 (mean 27.2 days, SD 6 days). Once after flap detachment the patients maintained the limb immobilized in a plaster cast for 5 weeks.Beside local abscess which was successfully treated with compresses, healing of the surgical site was uncomplicated. The bony union was assessed radiological and occurred after 9-13 weeks (mean 11.1 weeks, SD 5 weeks). Due to delayed bone union, one patient required bone slivers grafting which finally lead to unification. All the patients needed secondary plastic surgery of subcutaneous tissue of the flap; however, only 9 of them consented to it. In three patients we substituted the sensibility with a nerve graft according to Holevich.Results. The described operation did not improve function in patients with wrist-level and metacarpal osseous defects but improved its esthetical aspect; in the other patients the hand function was significantly restored.Conclusions. In patients disqualified for other methods of reconstructions of the thumb, fingers and bone defects of the hand a satisfactory result may be achieved by using pedicled osteocutaneous flaps from the iliac crest. This method proved to be highly effective.
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Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation investigated by scanning electron microscope based on an analysis of 140 patients

88%
Wiatr A., Job K., Składzień J., Wiatr M.
Polish Journal of Otolaryngology
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2021
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vol. 75
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issue 3
21-27
EN
Introduction: Chronic purulent cholesteatoma of the middle ear, as well as to a lesser extent chronic granulomatous otitis media, lead to destruction of bone structures within the middle ear space. The above process is controlled by the OPG/RANKL/RANK system. Aim: The aim of the study is a comparative analysis of surgical material obtained from patients with diagnosed chronić cholesteatoma and chronic otitis media with inflammatory granulation in the assessment of the Scanning Electron Microscope (SEM). Material and methods: An analysis of 140 patients operated on due to chronic otitis media was performed. Forty patients who had been diagnosed with chronic cholesteatoma of the middle ear and chronic granulomatous otitis media were selected for a detailed analysis in the SEM. The final study under SEM included 20 patients. Results: The regular structure of cholesteatoma depicted in the SEM concerned 5 patients. In the remaining 7 patients, the system was irregular and even chaotic. The lack of regularity can also be observed in the case of granulation tissue, which in the SEM image presented itself as an irregular tissue mass without detectable regularities. Conclusions: (1) The regular pattern of the cholesteatoma matrix cells observed in some patients with chronic cholesteatoma of the middle ear reduces the molecular permeability of inflammatory cytokines, concurrently limiting the destructive activity on bone structures; (2) the presence of inflammatory granulation tissue in the middle ear is accompanied by an influx of leukocytes: neutrophils and lymphocytes, which are the source of pro-inflammatory cytokines, the growth of which activates the processes leading to the damage of bone tissue and the development of inflammation; (3) no specimen of acquired cholesteatoma revealed the presence of commensal organisms from Demodex species on the surface of the exfoliated human epithelium.
3
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Autologous activated platelet-rich plasma (PRP) in bone tissue healing – does it work? Assessment of PRP effect on bone defect healing in animal models

88%
Skwarcz S., Bryzek I., Gregosiewicz A., Warda E., Gawęda K., Tarczyńska M., Węgłowski R., Skwarcz J., Nadulski R., Starek A., Sanford J., Skwarcz S., Bryzek I., Gregosiewicz A., Warda E., Gawęda K., Tarczyńska M., Węgłowski R., Skwarcz J., Nadulski R., Starek A., Sanford J.
Polish Journal of Veterinary Sciences
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2019
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issue 1
4
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The effect of activated platelet-rich plasma (PRP) on tricalcium hydroxyapatite phosphate healing in experimental, partial defects of long bone shafts in animal models

75%
Skwarcz S., Bryzek I., Gregosiewicz A., Warda E., Gawęda K., Tarczyńska M., Skwarcz J., Nadulski R., Starek A., Sanford J., Skwarcz S., Bryzek I., Gregosiewicz A., Warda E., Gawęda K., Tarczyńska M., Skwarcz J., Nadulski R., Starek A., Sanford J.
Polish Journal of Veterinary Sciences
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2019
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issue 2
5
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Jak chronić biomateriały przed układem odpornościowym?

51%
Ścisłowska-Czarnecka A., Kołaczkowska E.
Kosmos
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2017
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vol. 66
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issue 4
677-689
PL
Wprowadzając do organizmu człowieka biomateriał, musimy mieć pewność, że jest on biozgodny (nie cytotoksyczny czy karcynogenny) i że ryzyko aktywacji układu odpornościowego jest niewielkie. Grupa biomateriałów dopuszczonych do użytku medycznego jest obszerna, jednak wiele z nich nie spełnia jednocześnie wszystkich wymagań w zakresie biozgodności. Dlatego materiały przeznaczone do użytku medycznego są wciąż udoskonalane/modyfikowane w celu poprawy ich parametrów, a co za tym idzie, w celu ich jak najskuteczniejszego "ukrycia" przed układem odpornościowym. Jedną z najczęstszych, niepożądanych reakcji organizmu na biomateriał/implant jest odczyn zapalny. Dlatego wiele badań koncentruje się na wpływie implantów na komórki układu odpornościowego. Wykazano, że najczęściej obecnie stosowane modyfikacje biomateriałów, pokrycie ich powierzchni materiałem biologicznym, zmiana porowatości czy też dodatek nanocząsteczek, istotnie poprawiają ich właściwości, w tym osłabiają aktywację leukocytów. W obecnym opracowaniu opisujemy typy biomateriałów, sposoby ich modyfikacji oraz wpływ na komórki immunokompetentne z naciskiem na strategie, które pozwalają na uniknięcie aktywacji układu odpornościowego.
EN
Biocompatibility verification is required prior to implantation of any biomaterial into human body. This involves verification of its cytotoxic and carcinogenic effects, and confirmation of (only) weak activation of the immune system. A substantial number of biomaterials is currently used in medical procedures, however, many of them do not fulfill all biocompatibility requirements. Therefore nowadays materials aimed for medical application are being modified to improve their characteristics, and thus "hide" them more efficiently from the immune system. One of the most common, yet undesirable, responses to biomaterial/implant is inflammation. Because of this, numerous studies focus on immune cells and strategies to modify biomaterials in such ways that they induce only weak or mild, and short-lasting, activation of leukocytes. It has been documented that three approaches in particular are efficient in this regard - surface modification by its covering with biological substances/proteins, modification of surface porosity and addition of nanoparticles. Herein we described types of biomaterials, strategies of their modification and biomaterial impact on leukocytes. In particular, we focus on strategies used to minimize activation of the immune response.
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