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Biological activity of surfactins - a case of a biosurfactant produced by Bacillus subtilis PCM 1949

100%
Siwak E., Jewgiński M., Kustrzeba-Wójcicka I.
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2015
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vol. 62
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issue 4
875-878
EN
Biosurfactants are microbial surface active compounds which, contrary to synthetic surfactants, are natural in origin, biodegradable and less toxic to a human organism. For that reason, there is a great research potential in studies aimed at their purification, finding potential ways of their utilization and decreasing their production costs. This paper demonstrates the process of isolating and purifying a surfactin synthesized by Bacillus subtilis PCM 1949. Surfactin samples were prepared by a classical organic solvent extraction and were studied using mass spectrometry (MS). Analysis of the susceptibility profile of microorganisms utilized in the diffusion-plate tests demonstrated that their sensitivity to this surfactin is differentiated and depends on the microorganism species. In our studies, we found that the selected strains of bacteria and fungi were insensitive to this surfactin at a wide range of concentrations.
2
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Activity of the saponin extract from the bark of Quillaja saponaria Molina, against Colorado potato beetle (Leptinotarsa decemlineata Say)

88%
Waligóra D.
Journal of Plant Protection Research
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2006
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vol. 46
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issue 2
3
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Interactions of antitumor triazoloacridinones with DNA

75%
Koba M., Konopa J.
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2007
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vol. 54
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issue 2
297-306
EN
Triazoloacridinones (TA) are a new group of potent antitumor compounds, from which the most active derivative, C-1305, has been selected for extended preclinical trials. This study investigated the mechanism of TA binding to DNA. Initially, for selected six TA derivatives differing in chemical structures as well as cytotoxicity and antitumor activity, the capability of noncovalent DNA binding was analyzed. We showed that all triazoloacridinones studied stabilized the DNA duplex at a low-concentration buffer but not at a salt concentration corresponding to that in cells. DNA viscometric studies suggested that intercalation to DNA did not play a major role in the mechanism of the cytotoxic action of TA. Studies involving cultured cells revealed that triazoloacridinone C-1305 after previous metabolic activation induced the formation of interstrand crosslinks in DNA of some tumor and fibroblast cells in a dose dependent manner. However, the detection of crosslink formation was possible only when the activity of topoisomerase II in cells was lowered. Furthermore, it was impossible to validate the relevance of the ability to crosslink DNA to biological activity of TA derivatives.
4
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Influence of pesticides on the biological activity of light chestnut soils in South-East Kazakhstan

75%
Tukenova Z., Mustafayev M., Alimzhanova M., Akylbekova T., Ashimuly K., Tukenova Z., Mustafayev M., Alimzhanova M., Akylbekova T., Ashimuly K.
Journal of Water and Land Development
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2021
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issue 48
5
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Investigating the antibacterial and antifungal properties of few organic moieties: a comprehensive analysis

75%
Nisha S., Saravanan M., Ilavenil K. K.
World News of Natural Sciences
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2023
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vol. 50
33-41
EN
The existing work reveals the novel character of organic compounds like 4-Methoxyphenoxyacetic acid and p-dihydroxybenzene. The compounds were investigated for their antibacterial and antifungal prospective against gram-positive bacteria. At increasing doses of 2-Methoxyphenoxyacetic acid, the zone of inhibition for Salmonella paratyphi was (30 mm/ml) at 100 µl and p-dihydroxybenzene is more resistant to bacterial such as Bacillus subtilis (38 mm/ml), Enterococcus faecalis (40 mm/ml), Mucor (42 mm/ml), Aspergillus niger (40 mm/ml). The docking investigation was carried out using Auto Dock 4.2.6; interactions between hydrogen atoms and the smallest ligands with macromolecules had the lowest binding energies.
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