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Tigecycline - A New Antibiotic in Infections Treatment

100%

Stefaniuk E., Hryniewicz W.

Polish Journal of Surgery

2007

vol. 79

issue 9

587-593

Tigecycline, a member of a new class of antimicrobials (glycylcyclines), was shown to have expanded broad spectrum activity against most commonly encountered species responsible for community and hospital acquired infections, including Gram-positive and Gram-negative multidrug resistant bacterial strains.The aim of the study was to evaluate the activity of tigecycline against resistant bacterial strains commonly associated with nosocomial infections, including skin structure, subcutaneous layer and intra-abdominal infections.Material and methods. Ten general hospitals from different regions of Poland participated in the study. Antimicrobial susceptibility tests were carried for 539 isolates of different genus/species of bacterial strains isolated from patients hospitalized in hospitals throughout Poland. Minimal inhibitory concentrations (MICs) of tigecycline were determined using the broth dilution method.Results. Ten strains of 50 S. aureus isolates, i.e. 20%, were methicillin-resistant (MRSA). The lowest MIC90 values observed for tigecycline were (0.25 μg/ml); they were similar to the MIC50 for MSSA and MRSA.S. pneumoniae varied with respect to their susceptibility to penicillin. Twenty two percent of isolates (n=11) had decreased susceptibility to penicillin. However, all 50 strains of this species were susceptible to levofloxacin, vancomycin and linezolid. Tigecycline exhibited high activity against S. pneumoniae strains. Tigecycline MIC90 values for this group of strains were lower than MIC90 of the remaining antibiotics. One hundred percent of collected S. agalactiae strains were susceptible to all investigated antibiotics.Conclusion. The presented data indicate that tigecycline exhibits excellent inhibitory activity against nosocomial and community pathogens regardless of resistance patterns.

Recent developments in Neem (Azadirachta indica – A. Juss) derived antimicrobial constituents for control of human and plant diseases – a review

72%

Dohroo A., Karnwal A., Ghai M.

Annales Academiae Medicae Silesiensis

2016

vol. 70

220-223

Neem has immense biocontrol potential against a large number of pathogens causing various diseases in human beings and plants. The plant has maximum useful value in its leaves, bark,, flowers and fruits than any other tree species. These values include antiallergic, antidermatic, antifeedent, antifungal and anti-inflammatory properties. Due to the vast activities of neem, it has become extremely valuable in making our ecosystem a green treasure. Neem leaves have been demonstrated to exhibit immuno-modulatory, anti-inflammatory, antiulcer, antimalarial properties. Neem tree plant parts contain a promising pest control substance which has found effective use against economically important agricultural pests. Neem plant products are easy to process by village level industries on the micro scale level and use by resource poor farmers in crop protection resulting thereby in income generation. This plant also has antioxidant properties and free radical scavenging potential in its different extracted solvents. The present review highlights the properties of neem against the pathogens of living organisms for environmental protection.

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1 Annales Academiae Medicae Silesiensis

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1 Dohroo A.

1 Ghai M.

1 Hryniewicz W.

1 Karnwal A.

1 Stefaniuk E.

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Tigecycline - A New Antibiotic in Infections Treatment

Recent developments in Neem (Azadirachta indica – A. Juss) derived antimicrobial constituents for control of human and plant diseases – a review