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The influence of elastin degradation products, glucose and atorvastatin on metalloproteinase-1, -2, -9 and tissue inhibitor of metalloproteinases-1, -2, -3 expression in human retinal pigment epithelial cells

100%

Dorecka M., Francuz T., Garczorz W., Siemianowicz K., Romaniuk W.

Purpose: Hyperglycemia and increased concentrations of elastin degradation products (EDPs) are common findings in patients with diabetes, atherosclerosis and hypertension. The aim of this study was to assess the influence of high glucose, EDPs and atorvastatin on MMP-1, MMP-2, MMP-9 and TIMP1-3 gene expression in human retinal pigment epithelial cells (HRPE) in vitro. Method: HRPE were cultured for 24 hours with the substances being tested (glucose, EDPs), alone or in combination. Additionally, the cells were treated with atorvastatin in two different concentrations (1 or 10 μM). After incubation, total cellular RNA was extracted and used for gene expression evaluation. Gene expression was measured using the real-time RT-PCR technique. Results: Glucose, EDPs and atorvastatin had no impact on TIMP-1 and TIMP-3 expression. HRPE cells treated with glucose or EDPs with the addition of atorvastatin had a statistically significant decrease of TIMP-2 expression; glucose alone decreased MMP-1 expression. Atorvastatin decreased expression of all assessed genes, except TIMP-1 and TIMP-3 in a dose-dependent manner. Conclusions: Our results confirm the importance of MMPs and TIMPs in retinal vascular biology. Atorvastatin-induced MMPs gene expression can deeply affect extracellular matrix turnover, which may play an important role in the progression of ocular diseases.

Interindividual variability of atorvastatin treatment influence on the MPO gene expression in patients after acute myocardial infarction

88%

Sygitowicz G., Maciejak A., Piniewska-Juraszek J., Pawlak M., Góra M., Burzyńska B., Dłużniewski M., Opolski G., Sitkiewicz D.

2016

vol. 63

issue 1

89-95

Myeloperoxidase (MPO) and C-reactive protein (CRP) may play critical roles in generation of oxidative stress and the development of the systemic inflammatory response. The aim of the study was to determine the effect of atorvastatin therapy on the MPO gene expression and its plasma level in relation to lipids level lowering and an anti-inflammatory response in patients after acute myocardial infarction. The research material was represented by 112 samples. Thirty-eight patients with first AMI receiving atorvastatin therapy (40 mg/day) and followed up for one month were involved in the study. The relative MPO gene expression in peripheral blood mononuclear cells (PBMCs) was examined using RT-qPCR in 38 patients before-, 38 patients after-therapy and in 36 patients as the control group. The plasma concentrations of MPO and serum concentrations of biochemical parameters were determined using commercially available diagnostic tests. After one month of atorvastatin therapy, in 60.5% patients a decrease of MPO gene expression, whereas in 39.5% patients an increase, was observed. The plasma MPO levels behaved in the same way as the MPO gene expression. However, the serum lipids and CRP concentrations were significantly lower after one month of atorvastatin therapy in both groups of patients - with decreased and increased MPO gene expression. Atorvastatin exhibited a different effect on MPO gene expression and its plasma level. Short-term atorvastatin therapy resulted in lipid lowering and anti-inflammatory activity in patients after AMI, independently of its effect on MPO gene expression. The molecular mechanisms of this phenomenon are not yet defined and require further research.

Nowoczesna farmakoterapia kardiologiczna w świetle nowych wytycznych Europejskiego Towarzystwa Kardiologicznego z 2013 roku

51%

Szymański F. M.

Pediatria i Medycyna Rodzinna

2013

vol. 9

issue 3

232-236

This year, the European Society of Cardiology (ESC) has published new guidelines on the diagnosis and management of arterial hypertension, management of patients with stable coronary artery disease and guidelines on approach to cardiovascular disease in patients with diabetes and pre-diabetes. The incidence of all of these disorders in the general population is very high. In everyday clinical practice, physicians, regardless their specialties, very often face patients with arterial hypertension, diabetes or coronary artery disease. To treat patients in accordance with the latest recommendations, clinicians must constantly learn and expand their knowledge. In the context of the publication of the new guidelines it is particularly important to familiarize yourself with the newly introduced rules on pharmacotherapy in relation to newest findings published in recent years. In this field changes are the most dynamic and with a very high degree of influence on the treatment of patients. Some of pharmaceutical groups used in cardiology are gaining importance, others are slowly being replaced. Position of drug classes such as angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statins or aspirin in the treatment and prevention of cardiovascular events, in the current guidelines has been strengthened. However, in the case of these classes of drugs very important is the choice of specific substance, which will meet the expectations of both the effectiveness and safety in therapy. Present paper, in addition to summarizing the ESC most recent guidelines, demonstrates scientific evidence for the clinical efficacy of substances such as ramipril, telmisartan, atorvastatin or rosuvastatin in patients with diseases of the cardiovascular system.

W bieżącym roku Europejskie Towarzystwo Kardiologiczne (European Society of Cardiology, ESC) opublikowało nowe wytyczne dotyczące diagnostyki i leczenia nadciśnienia tętniczego, postępowania u chorych ze stabilną chorobą wieńcową oraz wytyczne dotyczące chorób układu sercowo-naczyniowego w grupie pacjentów z cukrzycą. Częstość występowania wszystkich tych schorzeń w populacji ogólnej jest bardzo wysoka. W codziennej praktyce klinicznej lekarze, niezależnie od wykonywanej specjalizacji, bardzo często spotykają się z pacjentami z nadciśnieniem tętniczym, cukrzycą czy chorobą wieńcową. Aby leczyć pacjentów zgodnie z najnowszymi zaleceniami, lekarze praktycy muszą stale pogłębiać swoją wiedzę. W kontekście publikacji nowych wytycznych szczególnie istotne jest zapoznanie się z wprowadzanymi zasadami dotyczącymi farmakoterapii – właśnie w stosunku do leczenia farmakologicznego obserwowane w ostatnich latach zmiany są najbardziej dynamiczne i w bardzo wysokim stopniu wpływają na sposób postępowania z pacjentami. Niektóre ze stosowanych w kardiologii grup farmaceutycznych zyskują na znaczeniu, inne powoli zastępowane są nowymi substancjami. W obecnych wytycznych pozycja inhibitorów konwertazy angiotensyny, blokerów receptora angiotensynowego, statyn oraz kwasu acetylosalicylowego w leczeniu oraz prewencji incydentów sercowo-naczyniowych została umocniona. Jednak w przypadku wymienionych grup leków bardzo istotny jest wybór substancji, która będzie spełniać oczekiwania dotyczące zarówno skuteczności działania, jak i bezpieczeństwa terapii. Poniższa praca, poza podsumowaniem najnowszych wytycznych ESC, pokazuje dowody naukowe potwierdzające skuteczność kliniczną takich substancji, jak ramipril, telmisartan, atorwastatyna czy rosuwastatyna, u pacjentów z chorobami układu sercowo-naczyniowego.

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2 Acta Biochimica Polonica

1 Pediatria i Medycyna Rodzinna

1 2016

1 2014

1 2013

1 Burzyńska B.

1 Dorecka M.

1 Dłużniewski M.

1 Francuz T.

1 Garczorz W.

1 Góra M.

1 Maciejak A.

1 Opolski G.

1 Pawlak M.

1 Piniewska-Juraszek J.

1 Romaniuk W.

1 Siemianowicz K.

1 Sitkiewicz D.

1 Sygitowicz G.

1 Szymański F. M.

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The influence of elastin degradation products, glucose and atorvastatin on metalloproteinase-1, -2, -9 and tissue inhibitor of metalloproteinases-1, -2, -3 expression in human retinal pigment epithelial cells

Interindividual variability of atorvastatin treatment influence on the MPO gene expression in patients after acute myocardial infarction

Nowoczesna farmakoterapia kardiologiczna w świetle nowych wytycznych Europejskiego Towarzystwa Kardiologicznego z 2013 roku