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SYNTHESIS, REACTIONS, AND APPLICATIONS OF HYDANTOIN AND 2-THIOHYDANTOIN DERIVATIVES

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Abd Elhady H., El Desoky S., Al-Shareef H. F., El-mekawy R.
Acta Poloniae Pharmaceutica - Drug Research
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2019
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vol. 76
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issue 6
971-986
EN
On account of the interesting pharmacological properties of hydantoin and 2-thiohydantoin derivatives, and other purposes such as textile printing, catalysts for polymerizations, their use in the production of resins and plastics, they have been the subject of chemical and biological studies. In this review article, we focused our interest on the most important methods for the synthesis of hydantoin and 2-thiohydantoin derivatives, different reactions and different application of them. We explored their antitumor, antimicrobial, antiviral, anxiolytic, antidiabetic, anticonvulsant activities, their utilities in treatment of vascular dysfunction, using them as an inhibitor of fatty acid amide hydrolase, using in hyperpigmentation applications, and utilities of them in the production of antimicrobial polyurethane coatings.
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