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1

The inhibition of methicillin-resistant Staphylococcus aureus by essential oils isolated from leaves and fruits of Schinus areira depending on their chemical compositions

100%

Celaya L., Alabrudzińska M., Molina A., Viturro C., Moreno S.

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EN

Schinus areira L. is a native plant from South America used for centuries in traditional medicine. Here, we investigate the antimicrobial activity of four essential oils extracted from leaves and fruits of S. areira exhibiting different chemical profiles. The antibacterial activity against the human pathogenic bacteria Staphylococcus aureus susceptible as well as methicillin resistant strain was assessed by the broth microdilution assay. The results showed that the limonene-rich oil extracted from the leaves and fruits have potent antibacterial effect on S. aureus ATCC 25923, while the α-phellandrene-rich fruit oil having a lower content of limonene showed the lowest antibacterial efficacy. In this work, for the first time, we demonstrated the bactericidal activity of essential oils isolated from fruits and leaves of S. areira against susceptible and methicillin resistant S. aureus strains. All results point out the potential use of the S. areira oils as antimicrobial agents to be used, at least against Staphylococcal infections.

2

Silver nanoparticles as an alternative strategy against bacterial biofilms

100%

Markowska K., Grudniak A., Wolska K.

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2013

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vol. 60

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issue 4

523-530

EN

Biofilms are complex bacterial communities that resist the action of antibiotics and the human immune system. Bacteria within biofilms are the cause of numerous, almost impossible to eradicate, persistent infections. Biofilms can form on many medical devices and implants, and so have an enormous impact on medicine. Due to the lack of effective anti-biofilm antibiotics, novel alternative compounds or strategies are urgently required. This review describes some of the latest approaches in the field of biofilm treatment. New anti-biofilm technologies target different stages in the biofilm formation process. Some act to modify the colonized biomaterials to make them resistant to biofilm formation. One potentially important candidate treatment uses silver nanoparticles that show anti-bacterial and anti-biofilm activity. The biological action of nano-silver is complex and seems to involve a number of pathways. However, there have been few reports on the anti-biofilm activity of silver nanoparticles and the precise mechanism underlying their action remains unresolved. Here, we describe some anti-biofilm approaches employing AgNPs and consider the challenges and problems that need to be addressed in order to make silver nanoparticles a part of an effective anti-biofilm strategy.

3

Plasma-chemical modifications of cellulose for biomedical applications

88%

Pavliňák D., Švachová V., Vojtek L., Zarzycká J., Hyršl P., Alberti M., Vojtová L.

Open Chemistry

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2015

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vol. 13

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issue 1

EN

A 6-carboxycellulose (in medicine known as “oxidized cellulose” or “oxycellulose”) is one of the cellulose derivatives popular in the field of surgery. Health products based on oxidized cellulose are great local hemostatics with unique bactericidal and fully bioabsorbable effects. Traditional process of native cellulose oxidation is described as a complex radical reaction in strong acidic liquid medium doped by toxic nitrous radicals (NO*). Our plasma-chemical reaction demonstrates a new synthesis method of oxidized cellulose with unique bactericidal effect. This plasma-chemical treatment is based on atmospheric plasma discharge in liquid medium leading to the oxidation of polysaccharide molecules resulting in oxycellulose. Final oxycellulose properties were evaluated by infrared spectroscopy and carboxyl content determination. The biological impact showed a strong germicidal effect.

4

In silico screening, synthesis, in vitro evaluations antibacterial and DPPH scavenging activity of some 1,3,5-trisubstituted 2-pyrazoline derivatives as dihydrofolate reductase inhibitors

88%

Suriya S., Mala V.

World News of Natural Sciences

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2018

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vol. 18

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issue 2

180-186

EN

In this work, synthesis of three pyrazoline derivatives (6-8) is described. (E)-1,3-(phenylsubstituted)-prop-2-en-1-one (3-5) is prepared by the reaction of substituted benzaldehyde with 4-methylacetophenone, whereas condensation cyclization of the same chalcones (3-5) with phenylhydrazine hydrate in ethanol yielded 6-8. The structures of the title compounds (6-8) were characterized by chemical reactions, elemental analysis, and spectral methods such as IR spectra. The synthesized chalcone and pyrazolines were evaluated for in-vitro antibacterial and antioxidant activities against standard. The zone of inhibition for some of the newly synthesized compounds showed notable antibacterial activity against selected bacterial strains when compared with ampicillin. Significant antioxidant activities were also shown by chalcone and pyrazolines.

5

Synthesis, Characterization, In-Vitro Antimicrobial Evaluation and Antioxidant Studies of Some Isoxazoline Derivatives

75%

Vishnupriya P., Rubala mary M.

World News of Natural Sciences

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2018

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vol. 18

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issue 2

72-78

EN

The tremendous rise in development of resistance to antimicrobials has created an alarming situation for researchers and clinicians. In this regard, an attempt has been made to develop a series of azole-based derivatives. The presented study consists of the design and synthesis of some newer derivatives by incorporating the isoxazole nucleus in the pharmacophore. These are also characterized physicochemically and by spectral means (IR and microanalysis). Moreover, the antioxidant activity of these derivatives was assessed using DPPH radical scavenging methods Finally, all of the newly isolated compounds were tested for their antimicrobial activities. Herein, antimicrobial screening using the agar disc diffusion method revealed that the majority of the derivatives are most active.

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2 Acta Biochimica Polonica

2 World News of Natural Sciences

1 Open Chemistry

2 2018

2 2014

1 2013

1 Alabrudzińska M.

1 Alberti M.

1 Celaya L.

1 Grudniak A.

1 Hyršl P.

1 Mala V.

1 Markowska K.

1 Molina A.

1 Moreno S.

1 Pavliňák D.

1 Rubala mary M.

1 Suriya S.

1 Vishnupriya P.

1 Viturro C.

1 Vojtek L.

1 Vojtová L.

1 Wolska K.

1 Zarzycká J.

1 Švachová V.

The inhibition of methicillin-resistant Staphylococcus aureus by essential oils isolated from leaves and fruits of Schinus areira depending on their chemical compositions

Silver nanoparticles as an alternative strategy against bacterial biofilms

Plasma-chemical modifications of cellulose for biomedical applications

In silico screening, synthesis, in vitro evaluations antibacterial and DPPH scavenging activity of some 1,3,5-trisubstituted 2-pyrazoline derivatives as dihydrofolate reductase inhibitors

Synthesis, Characterization, In-Vitro Antimicrobial Evaluation and Antioxidant Studies of Some Isoxazoline Derivatives