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The use of over-the-counter analgesics in patients with chronic kidney disease

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Jakimowicz-Tylicka M., Chmielewski M., Kuźmiuk-Glembin I., Skonieczny P., Dijakiewicz G., Zdrojewska G., Rutkowski B., Tylicki L., Dębska-Ślizień A.
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2019
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vol. 1
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issue 2
11-16
EN
Background Analgesics can be sold following medical prescription, but also as over-the-counter (OTC) medications. In patients with chronic kidney disease (CKD), their use could potentially be associated with increased risk of side-effects, due to impaired renal elimination. The aim was to evaluate the epidemiology and indications for the use of OTC analgesics, and the knowledge of their side-effects in patients with CKD. Material and methods A cross-sectional, controlled survey on the use of OTC analgesic drugs was conducted among 180 CKD patients (stage 1-5, dialysis, kidney transplant), compared to 60 controls. Results The proportion of patients using OTC analgesics on a regular basis was higher in the CKD group, compared to controls (18.9% vs. 10.0%, p<0.02). The major indications included musculoskeletal issues, followed by headaches and other. Subgroup analysis revealed that analgesic use was lowest among transplanted patients, in comparison to CKD stage 1-5, and dialysis subjects (10%, 20%, 26%, respectively, p=0.06). Less than half of CKD patients and controls declared any knowledge on potential side-effects of analgesic drugs (45.6% vs. 40.0%, NS). Conclusions The use of OTC analgesics among patients with CKD is higher than in subjects without CKD, with the exception of transplanted patients. The knowledge on the potential side-effect of analgesics is limited.
2
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The use of over-the-counter analgesics in patients with chronic kidney disease

100%
Jakimowicz-Tylicka M., Chmielewski M., Kuźmiuk-Glembin I., Skonieczny P., Dijakiewicz G., Zdrojewska G., Rutkowski B., Tylicki L., Dębska-Ślizień A.
|
EN
Background: Analgesics can be sold following medical prescription, but also as over-the-counter (OTC) medications. In patients with chronic kidney disease (CKD), their use could potentially be associated with increased risk of side-effects, due to impaired renal elimination. The aim was to evaluate the epidemiology and indications for the use of OTC analgesics, and the knowledge of their side-effects in patients with CKD. Material and methods: A cross-sectional, controlled survey on the use of OTC analgesic drugs was conducted among 180 CKD patients (stage 1-5, dialysis, kidney transplant), compared to 60 controls. Results: The proportion of patients using OTC analgesics on a regular basis was higher in the CKD group, compared to controls (18.9% vs. 10.0%, p<0.02). The major indications included musculoskeletal issues, followed by headaches and other. Subgroup analysis revealed that analgesic use was lowest among transplanted patients, in comparison to CKD stage 1-5, and dialysis subjects (10%, 20%, 26%, respectively, p=0.06). Less than half of CKD patients and controls declared any knowledge on potential side-effects of analgesic drugs (45.6% vs. 40.0%, NS). Conclusions: The use of OTC analgesics among patients with CKD is higher than in subjects without CKD, with the exception of transplanted patients. The knowledge on the potential side-effect of analgesics is limited.
3
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Parameters of vibration stimulation for the relief of pain of different origins and locations

63%
Pasterczyk-Szczurek A., Pogwizd P., Bigosińska M.
Medical Rehabilitation
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2018
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vol. 22(2)
20-29
PL
Wstęp: Wykorzystanie stymulacji drganiami w łagodzeniu dolegliwości bólowych różnego pochodzenia i lokalizacji jest zagadnieniem pojawiającym się coraz częściej we współczesnej rehabilitacji. Cel pracy: Celem pracy było dokonanie przeglądu piśmiennictwa, dotyczącego terapeutycznego wykorzystywania wibracji w działaniu przeciwbólowym. Materiał i metody: Poszukiwania oparto na wynikach, dotyczących łagodzenia bólu przy pomocy wibroterapii w terapii schorzeń różnego pochodzenia i lokalizacji oraz przy rozmaitych zabiegach fizykoterapeutycznych/leczniczych. Opisano najważniejsze parametry takie jak: częstotliwość, amplituda, miejsca aplikacji do ciała, czy czas ekspozycji, które zostały opisane na podstawie wybranych testów. Rozpatrywano piśmiennictwo w języku polskim i angielskim. Większość znalezionych opracowań stanowiły artykuły anglojęzyczne (ponad 93%). W celu zgromadzenia danych przeszukano następujące bazy danych: Medline, Embase, Cochrane, ScienceDirect, PubMed, IEEE Xplore, Wiley Online Library. Słowa kluczowe: ból, wibracja, WBV, przeciwbólowy. Wymienione źródła zostały zakwalifikowane na podstawie: dostępności, weryfikacji danych, wyboru materiału badawczego i systematyczności aktualizacji. Podsumowanie i wnioski: Podczas, gdy ból ostry jest z definicji krótkim i samo ograniczającym się procesem, ból przewlekły zaczyna dominować w życiu wielu chorych oraz ich rodzin. Oprócz znacznego pogorszenia jakości życia, ból przewlekły narzuca duże obciążenia finansowe. Wykorzystanie stymulacji drganiami może stanowić rozwiązanie. Dlatego proponuje się dalsze analizy parametrów wibroterapii w działaniu przeciwbólowym, które mogą stworzyć podwaliny do „spersonalizowanej medycyny łagodzenia bólu”, która jasno określi standardy parametrów terapii wibracyjnej.
EN
The use of vibration stimulation in alleviating pain is an issue appearing more and more often in modern rehabilitation. The aim of the work was to review literature regarding the therapeutic usage of vibrations in analgesic activity. Searches based on the effect of alleviating pain with the help of vibrotherapy in the therapy of diseases of various origins and localizations, as well as with various physical therapy treatments and modalities. The most important parameters were determined, such as: frequency, amplitude, places of application, and exposure time, and were described on the basis of selected tests. Both the Polish and English-language literature has been discussed. Most of the studies were English-language (over 93%). The searches were carried out among the following databases: Medline, Embase, Cochrane, ScienceDirect, PubMed, IEEE Xplore, Wiley Online Library. The key words used were: pain, vibration, WBV, analgesics. The mentioned sources were qualified on the basis of: availability, data verification, selection of research material and regularity of update. While acute pain is, by definition, a short and self-limiting process, chronic pain begins to dominate life and concerns the patient and his/her family. In addition to significant deterioration in quality of life, chronic pain imposes a large financial burden. The use of vibrotherapy can be a solution. Therefore, it is proposed to further analyse the parameters of vibrotherapy in analgesic activity, which may lay the foundation for "personalized pain relief medicine", which will clearly define the standards of vibrational therapy parameters. pain, vibration, WBV, analgesics
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