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Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis

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Zuwała-Jagiełło J., Pazgan-Simon M., Simon K., Warwas M.
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2011
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vol. 58
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issue 1
59-65
EN
Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis. In the present study, we investigated the association between chronic inflammatory response triggered by AOPPs and the severity of liver disease as assessed by the Child-Pugh score. Plasma concentrations of AOPPs and inflammatory markers such as C-reactive protein, tumor necrosis factor-α, and interleukin-6 were measured in 41 patients with HCV-related cirrhosis, 43 patients with alcohol-related liver cirrhosis (ALC), and in 30 age and sex matched controls. In comparison with controls, AOPPs were increased in HCV-related compensated (Child-Pugh A) and decompensated (Child-Pugh B-C) cirrhosis and in alcohol-related compensated cirrhosis. AOPPs level positively correlated with Child-Pugh score in alcohol-related cirrhosis but not in HCV-related cirrhosis and the correlation with the indices of chronic inflammation was stronger in ALC. In turn, AOPPs in HCV-related cirrhosis was related to inflammation to a lesser extent, but a significant correlation with antioxidant defense could be noted. In summary, liver cirrhosis was associated with increased formation of AOPPs, which differed between alcohol-related and HCV-related cirrhosis with respect to the relationship between AOPPs and antioxidant defense, stage of liver cirrhosis, and inflammatory response. The significant correlation between AOPPs accumulation and indices of chronic inflammation, more specifically TNF-α, suggests that oxidative stress may be a mediator of chronic inflammatory state in the early stage of alcohol-related cirrhosis.
2
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Elevated advanced oxidation protein products levels in patients with liver cirrhosis

100%
Zuwała-Jagiełło J., Pazgan-Simon M., Simon K., Warwas M.
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issue 4
679-685
EN
Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.
3
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Biomarkery wykorzystywane w ocenie oksydacyjnych uszkodzeń białek

51%
Ognik K., Cholewińska E.
Kosmos
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2018
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vol. 67
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issue 2
347-359
PL
Przewaga procesów prooksydacyjnych w organizmie skutkuje wystąpieniem stresu oksydacyjnego objawiającego się m.in. utlenianiem białek. Bezpośrednia analiza ilości reaktywnych form tlenu i azotu jest zadaniem bardzo trudnym, dlatego w ocenie nasilenia stresu oksydacyjnego częściej wykorzystuje się markery uszkodzeń, powstające w wyniku reakcji wolnych rodników z białkami. Są one o wiele trwalsze, a przez to łatwiejsze do analizy. Wśród najważniejszych biomarkerów oksydacyjnych uszkodzeń białek wyróżnia się pochodne karbonylowe, 3-nitrotyrozynę, S-nitrotriazole, kynureninę, 3-chlorotyrozynę, bromotyrozynę, sulfotlenek metioniny, dityrozynę, oksohistydynę oraz tzw. zaawansowane produkty oksydacji białek (AOPP). W ocenie oksydacyjnych uszkodzeń białek u zwierząt laboratoryjnych najlepiej sprawdzają się pochodne karbonylowe, 3-nitrotyrozyna i AOPP. Ich zawartość w ustroju wyraźnie wzrasta w odpowiedzi na stres oksydacyjny wywołany takimi czynnikami, jak: niewłaściwa dieta, niedobór mikroelementów, zatrucie substancjami toksycznymi, infekcje czy starzenie.
EN
The prevalence of prooxidative processes in the body is associated with development of oxidative stress, one of the symptoms of which is oxidation of proteins. Direct analysis of the amount of reactive forms of oxygen and nitrogen is a very difficult task. Therefore, in assessing the severity of oxidative stress, markers generated by free radical reactions with proteins are often used. They are much more durable and thus easier to analyze. The most important biomarkers of oxidative damage of proteins are protein carbonyl compounds, 3-nitrothyrosine, S-nitrotriazoles, kynurenine, 3-chlorothyrozine, bromothyroxine, methionine sulfoxide, dithyrosine, oxohistidine and and so called advanced oxidation protein products (AOPP). Protein carbonyls, 3-nitrotyrosine and AOPP are the best indicators for evaluating of oxidative damage of proteins in laboratory animals. Their content in the body is clearly increasing in response to oxidative stress caused by such factors as improper diet, micronutrient deficiencies, toxic poisoning, infections or aging.
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