Search results

1

Adenocarcinoma of the Small Bowel – A Case Report

100%

Kulesza J., Meszka M., Rykała C., Pawlak J.

Polish Journal of Surgery

|

2015

|

vol. 86

|

issue 6

285-288

EN

The paper presents a rare case of a patient with adenocarcinoma of the small intestine who reported to the hospital due to non-specific gastrointestinal symptoms. Following diagnostic examinations, the patient underwent a surgery. The post-operative period proceeded with no complications. The case presented below confirms the usefulness of imaging examinations (abdominal CT) when pathologies within the small intestine are suspected. An accurate interpretation of the result was an indication for a surgical intervention, but the final diagnosis is still established on the basis of the histopathological examination

2

Primary Adenocarcinoma of the Appendix – A Case Report

100%

Pasternak A., Pach R., Szura M., Solecki R., Tomaszewski K. A., Szczepański W., Matyja A., Kulig J.

Polish Journal of Surgery

|

2015

|

vol. 86

|

issue 7

333-336

EN

Primary adenocarcinoma of the vermiform appendix is a rare clinical condition. It usually presents as an acute abdominal process or as a mass in the right lower quadrant. The gross pathologic and microscopic characteristics of this disease are the same as for colon carcinoma and carry a serious prognosis. We report a case of a 64-year old male patient presenting symptoms of acute appendicitis. The patient underwent laparoscopic appendectomy that revealed a severely inflamed appendix. Histopathological examination has shown that it was a poorly differentiated, high grade adenocarcinoma invading the periappendicular fat. According to the histopathological findings, a right hemicolectomy was further advised and performed. Right hemicolectomy is the generally recommended method of treatment for invasive adenocarcinoma of the appendix

3

Multifocal colorectal cancer in ulcerative colitis patient with sclerosing cholangitis – case report

100%

Kosmowska A., Krokowicz P., Nelke M.

Polish Journal of Surgery

|

2020

|

vol. 92(6)

51-54

EN

Introduction: U lcerative colitis (CU) is an inflammatory disease predisposing to colorectal cancer. Colorectal cancer in ulcerative colitis is more often metachronous or synchronous. Case report: In this case report we present a patient with multifocal colorectal cancer in the course of CU and operative treatment that was implemented. Additionallyprimary sclerosing cholangitis was diagnosed in this patient post-operatively.

4

A rare case of high-grade sarcoma as a true mixed tumor of the parotid gland – case report

88%

Kolary-Siekierska K., Jałocha-Kaczka A., Olszewski J.

Polski Przegląd Otorynolaryngologiczny

|

2020

|

vol. 9(3)

59-64

EN

Introduction: According to the National Cancer Registry, head and neck cancers account for 5.5 to 6.2% of all malignancies, which translates into about 5,500 to 6,000 new cases per year. Salivary gland tumors are a heterogeneous group of cancers, which results from the complex embryogenesis of salivary glands; they are divided into benign and malignant tumors. Common benign tumors include mixed tumors and Warthin tumors. Carcinosarcoma is called a true malignant mixed tumor because the tumor process involves both epithelial and mesenchymal elements. We reported the case of true malignant mixed tumor comprising three components: adenocarcinoma, synovial sarcoma (80%) and osteosarcoma (20%). This tumor develops rapidly and has an adverse course with a tendency to form metastases. Case report: The work presents a case report of a 65-year-old patient who reported to the Department of Otolaryngology, ENT Oncology, Audiology and Phoniatrics at the WAM Hospital due to a tumor of the right parotid gland. The patient was concerned with the rapid growth of the tumor that occurred within 2 months prior to hospitalization, causing deformation of facial features. ENT examination revealed a polycyclic tumor with limited mobility and asymmetry of the corners of the mouth (lowering on the right side). FNA diagnosed typical cancer cells suggesting malignant growth. The patient was qualified for surgical treatment. Under general anesthesia, the right parotid gland tumor with superficial lobe of the salivary gland and region II cervical lymphadenectomy on this side were removed. The postoperative course was normal. Postoperative histopathological examination described high -rade malignant parotid carcinoma, pT3Nx. The patient was referred to an oncology center to undergo radiotherapy.

5

Vascular Endothelial Growth Factor and Survivin Immunostaining in Gastric Adenocarcinoma

75%

Bury J., Szumiło J., Dąbrowski A., Ciechański A., Śliwińska J., Wallner G.

Polish Journal of Surgery

|

2012

|

vol. 84

|

issue 7

341-347

EN

Two molecules - vascular endothelial growth factor involved in new vessels formation and survivin - antiapoptotic protein, reported to be associated with worse prognosis in various malignancies have been chosen for the study. Both are potential target for novel therapiesThe aim of the study was to determine the immunostaining of VEGF and survivin in gastric carcinoma and to analyse their relationship to the selected clinicopathological features and survival.Material and methods. Formalin-fixed, paraffin-embedded sections from 41 gastric adenocarcinomas were used for immunohistochemical reaction with monoclonal antibodies against vascular endothelial growth factor and survivin. The results were compared with selected clinicopathological features and survival.Results. Positive immunohistochemical reaction for vascular endothelial growth factor and survivin was revealed in 24 (58,53%) and 30 (73,17%), gastric carcinomas respectively. Vascular endothelial growth factor-negative gastric carcinomas were significantly more common in cases without metastases to regional lymph nodes and distant organs and in less advanced cases. Similar, distant metastases were also statistically less common in survivin-negative carcinomas. The differences in immunohistochemical reactions for survivin between less and more advanced cases almost reach statistical significance. The only factors significantly influenced 1, 2 and 3-year survival were vascular endothelial growth factor and survivin status. Statistically significant higher percentage of survival was noted in patients with vascular endothelial growth factor- and survivin-negative tumors.Conclusions. It seems that vascular endothelial growth factor and survivin play role in local invasion and spread of gastric adenocarcinoma and negatively influences survival. However, further studies are required to assess their true usefulness in the clinical practice.

6

Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice. A multiple case study

75%

Jakubowska M., Śniegocka M., Podgórska E., Michalczyk-Wetula D., Urbanska K., Susz A., Fiedor L., Pyka J., Płonka P.

|

2013

|

vol. 60

|

issue 3

323-330

EN

Lung adenocarcinoma is a leading human malignancy with fatal prognosis. Ninety percent of the deaths, however, are caused by metastases. The model of subcutaneous tumor xenograft in nude mice was adopted to study the growth of control and photodynamically treated tumors derived from the human A549 lung adenocarcinoma cell line. As a side-result of the primary studies, observations on the metastasis of these tumors to the murine lungs were collected, and reported in the present paper. The metastasizing primary tumors were drained by a prominent number of lymphatic vessels. The metastatic tissue revealed the morphology of well-differentiated or trans-differentiated adenocarcinoma. Further histological and histochemical analyses demonstrated the presence of golden-brown granules in the metastatic tissue, similar to these found in the tumor tissue. In contrast to the primary tumors, the electron paramagnetic resonance spectroscopy revealed no nitric oxide - hemoglobin complexes (a source of intense paramagnetic signals), in the metastases. No metastases were found in other murine organs; however, white infarctions were identified in a single liver. Taken together, the A549-derived tumors growing subcutaneously in nude mice can metastasize and grow on site in the pulmonary tissue. Thus, they can represent an alternative for the model of induced metastatic nodule formation, following intravenous administration of the cancerous cells.

7

Podstawowe zasady leczenia przełyku Barretta

63%

Wojtuń S., Gil J., Florek M.

|

issue 4

308-314

EN

Barrett’s oesophagus, reflux disease complication is a raising and important clinical issue. Basic diagnostic tool facilitating intestinal metaplasia diagnosis in squamous epithelium of lower part of oesophagus is endoscopy with histopathological samples. Because of high risk of malignant transformation endoscopic surveillance is required in patients with Barrett’s oesophagus. On the basis of histopathological type of lesion, length, and its location different procedure should be implemented. In the paper we discuss current treatment paradigm of Barrett’s oesophagus. Pharmacotherapy and anti‑reflux procedures can be implemented in patients with symptoms and without dysplasia. Endoscopic procedures (mucosectomy) or surgical (lower part of oesophagus removal) should be used in patients with high grade dysplasia and adenocarcinoma. In case of neoplastic lesion findings following rules should be used. Neoplastic lesion of low grade – endoscopic resection all visible lesions. In case of high grade neoplasia lesions endoscopic resection of all neoplastic lesions and all Barrett’s epithelium ablation is required. In case of patients with Barrett’s oesophagus and high grade dysplasia or intraepithelial carcinoma when oesophagus removal is planned they should be referred to surgical centers specialized in upper part of gastrointestinal tract cancer and dysplasia treatment.

PL

Przełyk Barretta jako powikłanie choroby refluksowej przełyku stanowi istotny i narastający problem kliniczny. Wiemy, że nadal podstawowym badaniem pozwalającym na stwierdzenie obecności metaplazji jelitowej w obrębie nabłonka wielowarstwowego płaskiego w dolnym odcinku przełyku jest klasyczne badanie endoskopowe z pobraniem wycinków do badania histopatologicznego. Ponieważ istnieje wysokie ryzyko transformacji nowotworowej w przełyku Barretta, w pracy wskazano na potrzebę prowadzenia nadzoru endoskopowego u tych chorych. W zależności od rozpoznania histopatologicznego, typu zmiany i długości zajmowanego odcinka ustala się sposób postępowania z chorym. W artykule omówiono współczesne metody leczenia przełyku Barretta. U chorych z dolegliwościami klinicznymi i bez dysplazji zastosowanie mają farmakoterapia lub zabiegi antyrefluksowe, z kolei u chorych z dysplazją wysokiego stopnia i gruczolakorakiem stosuje się zabiegi endoskopowe (mukozektomia) lub chirurgiczne (wycięcie dolnego odcinka przełyku). W przypadku stwierdzenia zmian neoplastycznych proponuje się następujące zasady postępowania: neoplazja niskiego stopnia wymaga resekcji endoskopowej wszystkich widocznych zmian, neoplazja wysokiego stopnia – resekcji endoskopowej wszystkich ognisk neoplastycznych i ablacji pozostałego nabłonka Barretta. Chorych z przełykiem Barretta z dysplazją wysokiego stopnia lub z rakiem śródnabłonkowym, u których rozważa się wycięcie przełyku, należy kierować do ośrodków chirurgicznych specjalizujących się w leczeniu raka i dysplazji wysokiego stopnia w górnym odcinku przewodu pokarmowego.

8

Wpływ wybranych cytokin prozapalnych oraz stresu oksydacyjnego na kancerogenezę i progresję gruczolakoraków jelita i prostaty

51%

Fryczkowski M., Hejmo T., Bułdak M., Stachowska M., Rokicka J., Żwirska-Korczala K.

|

issue 73

182-193

EN

Colorectal and prostate cancers have one of highest occurrence rate in Poland and the incidence is constantly increasing. Chronic inflammation and oxidative stress are known factors that promotes the development of cancer. Pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α are produced in normal cells and are responsible for controlling key processes. However overproduction associated with chronic inflammation may induce tumor transformation and support tumor growth by expression of cytokines by tumor microenvironment cells. The concentration of pro-inflammatory cytokines in the serum and expression in tumor tissue may be a diagnostic and prognostic factor for patients with colorectal or prostate cancer, and anti-cytokine therapy may increase patients survival.

PL

Nowotwory jelita grubego i prostaty są jednymi z najczęściej występujących nowotworów w Polsce, a zapadalność na nie stale rośnie. Przewlekły stan zapalny i stres oksydacyjny są znanymi czynnikami promującymi rozwój nowotworów. Cytokiny prozapalne, takie jak IL-1β, IL-6, IL-8 oraz TNF-α, są wytwarzane w prawidłowych komórkach i odpowiadają za kontrolę kluczowych procesów. Związana z występowaniem przewlekłego stanu zapalnego nadprodukcja może jednak indukować transformację nowotworową, a następnie wspomagać rozwój nowotworu przez ekspresję cytokin przez komórki mikrośrodowiska guza. Stężenie cytokin prozapalnych w surowicy krwi oraz ekspresja w tkance guza mogą być czynnikami diagnostycznymi i prognostycznymi u pacjentów chorych na raka jelita grubego lub prostaty, a terapia antycytokinowa może wydłużyć czas ich przeżycia.

Refine search results

Adenocarcinoma of the Small Bowel – A Case Report

Primary Adenocarcinoma of the Appendix – A Case Report

Multifocal colorectal cancer in ulcerative colitis patient with sclerosing cholangitis – case report

A rare case of high-grade sarcoma as a true mixed tumor of the parotid gland – case report

Vascular Endothelial Growth Factor and Survivin Immunostaining in Gastric Adenocarcinoma

Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice. A multiple case study

Podstawowe zasady leczenia przełyku Barretta

Wpływ wybranych cytokin prozapalnych oraz stresu oksydacyjnego na kancerogenezę i progresję gruczolakoraków jelita i prostaty