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Effect of a bicarbonate-buffered peritoneal dialysis solution on clinical and laboratory indices of dialysis adequacy

100%
Chmielewski M., Bielińska-Ogrodnik D., Jagodziński P., Lichodziejewska-Niemierko M.
European Journal of Translational and Clinical Medicine
|
2020
|
vol. 3
|
issue 1
11-15
EN
Background: Biocompatible fluids were introduced to improve dialysis and patient outcome in end-stage renal disease. However, being buffered with lactate, they may insufficiently correct metabolic acidosis, and lead to changes in peritoneum structure. Bicarbonate buffered fluids might mitigate these complications. The aim of the study was to evaluate the influence of a bicarbonate dialysis fluid on clinical and laboratory indices of dialysis adequacy. Material and methods: 20 prevalent peritoneal dialysis (PD) patients created two groups. One group continued on lactate fluid, the other changed to bicarbonate solution. Clinical and laboratory indices of dialysis adequacy were evaluated at baseline, and at six weeks intervals for 24 weeks. Results: In bicarbonate group, pH was 7.36±0.03, HCO3 22.1±1.8 mmol/l at baseline and 7.36±0.04 and 21.2± 2.3 mmol/l at 24 weeks, while in controls pH equaled 7.35±0.12, HCO3 22.2±1.4 mmol/l, at baseline, and 7.40±0.03, and 22.3±1.8 mmol/l, at 24 weeks, with no significant differences. Dialysis adequacy (urea Kt/V), urine output and dialysis ultrafiltration did not differ between the groups, either at baseline or at study termination. Conclusions: Bicarbonate PD solution appears to be similar to standard fluid in the impact on hydration status and on acid/base balance. Longitudinal studies are needed to assess long-term advantages of these biocompatible solutions.
2
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Effect of a bicarbonate-buffered peritoneal dialysis solution on clinical and laboratory indices of dialysis adequacy

100%
Chmielewski M., Bielińska-Ogrodnik D., Jagodziński P., Lichodziejewska-Niemierko M.
|
2020
|
vol. 3
|
issue 1
11-15
EN
Background Biocompatible fluids were introduced to improve dialysis and patient outcome in end-stage renal disease. However, being buffered with lactate, they may insufficiently correct metabolic acidosis, and lead to changes in peritoneum structure. Bicarbonate buffered fluids might mitigate these complications. The aim of the study was to evaluate the influence of a bicarbonate dialysis fluid on clinical and laboratory indices of dialysis adequacy. Material and methods 20 prevalent peritoneal dialysis (PD) patients created two groups. One group continued on lactate fluid, the other changed to bicarbonate solution. Clinical and laboratory indices of dialysis adequacy were evaluated at baseline, and at six weeks intervals for 24 weeks. Results In bicarbonate group, pH was 7.36±0.03, HCO3 22.1±1.8 mmol/l at baseline and 7.36±0.04 and 21.2± 2.3 mmol/l at 24 weeks, while in controls pH equaled 7.35±0.12, HCO3 22.2±1.4 mmol/l, at baseline, and 7.40±0.03, and 22.3±1.8 mmol/l, at 24 weeks, with no significant differences. Dialysis adequacy (urea Kt/V), urine output and dialysis ultrafiltration did not differ between the groups, either at baseline or at study termination. Conclusions Bicarbonate PD solution appears to be similar to standard fluid in the impact on hydration status and on acid/base balance. Longitudinal studies are needed to assess long-term advantages of these biocompatible solutions.
3
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The Influence of Different Types of Rest on Football Players’ Ability to Repeat Phosphagen Exercise

88%
Wolański P., Zatoń M., Murawska-Ciałowicz E.
Central European Journal of Sport Sciences and Medicine
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2016
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vol. 13
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issue 1
89-99
EN
The aim of the study was to asses the influence of the type of rest on football players’ ability to repeat a phosphagen exercise. Twelve football players from the Polish third league were involved in the study and were subjected to a maximum power test on a cycloergometer. Respiratory parameters, lactic acid concentration in capillary blood and acid-base balance parameters were registered before, during and after the test. The test was carried out twice. During the first test the subjects used an active rest break (A) and during the second one they used a passive rest break (B). In part A the quantity of relative work was 87.61 ±9.25 J/kg and in part B it was 78.5 ±6.58 J/kg (p = 0.012). In test A during exertion and during restitution (4th minute) we registered higher values of the respiratory parameters (Rf, VE, VO2, VO2/kg). Our conclusion is that passive rest should be used when the objective is the fastest resynthesis of PCr and ATP. An active rest break should be used when the goal is to remove the accumulated LA as soon as possible.
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