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1

Heart of transgenic pigs as a substitute of human heart. Expectations and reality

100%
Grzybowski G., Lubieniecka J., Kantoch M. J.
Biotechnologia
|
1998
|
issue 3
21-34
EN
The authors discuss hopes and fears, expectations and reality of xenotransplantations.
2

Biotechnological, organizational, legal and ethical aspects of xenotransplantation

80%
Smorag Z.
Biotechnologia
|
2006
|
issue 1
103-109
EN
The paper presents issues that shall be considered and elaborated before xenotransplantation reaches clinical stage. In a scope of a research project, such considerations as rules and procedures of a donor selection, including nature of its genetic modifications, must be undertaken. Another problem are regulatory requirements concerning pre-clinical tests on primates. Detailed conditions and requirements that must be fulfilled before clinical trials start are also discussed in the paper. Patient selection criteria as well as relationship with him/her before and after transplantation shall be clarified. A matter of high importance are organisational guidelines and relevant legal aspects of donor animals, breeding and xenotransplantation product harvesting, as well as ethical dimension of these actions.
3

Viral infections in xenotransplantation and their detection strategies

80%
Mazurek U., Janikowska G., Wydmuch Z., Wilczok T.
Biotechnologia
|
2006
|
issue 1
125-132
EN
Utilizing animals as organ donors for humans may cause transmission of foreign species pathogens to the recipient. To minimize the risk of transmission of infectious diseases from animals to humans, the strategy of appropriate animal selection is being assessed. The aim of the selection of specific pathogen-free pigs was the differentiation of active viruses from latent ones in both the recipients and donors in search of the host gene expression profiles which would differentiate the beginning of transplant rejection from an active infection. Additionally, the researchers searched for gene profile expressions indicating the type of infection which would considerably reduce the time of detection, and the cause of disease in the recipient which would offer a better chance of a positive result of the surgery.
4

The organ transplantation ? a challenge for biotechnology

80%
Jasinski A., Slomski R., Szalata M., Lipinski D.
Biotechnologia
|
2006
|
issue 1
7-28
EN
The use of animals as a source of organs and tissues for xenotransplantation can overcome the growing shortage of human organ donors. However, xenoreactive antibodies present in humans directed against swine Gal antigen on the surface of xenograft donor cells leads to the complement activation and immediate xenograft rejection as a consequence of hyperacute immunological reaction. The graft of genetically modified organ of a swine would be tolerated with simultaneous administration of medicines decreasing other less severe immunological reactions. This review summarizes the clinical history and rationale for xenotransplantation, recent progress in understanding the physiologic, immunologic, and infectious obstacles to xenotransplantation and some of the strategies being pursued to overcome these dificulties.
5

The role of domestic pig in somatic cell cloning and transgenesis

70%
Skrzyszowska M., Samiec M.
Biotechnologia
|
2006
|
issue 1
53-67
EN
A stimulus for development of the studies on pig somatic cell cloning, especially in recent years, was above all the possibility of its practical application for production of transgenic piglets using in vitro transfected nuclear donor cells and multiplication of genetically-engineered sows and boars generated so far, on the grounds of important implications for biomedicine, pharmacy and agriculture. However, effective pig somatic cell nuclear transfer, avoiding the sexual reproduction pathway, creates a possibility of providing numerous monogenetic and monosexual offspring derived not only from genetically-transformed individuals, but also from adult (postpubertal) animals of high genetic merit. Generation of cloned transgenic pigs for biomedical purposes to obtain recombinant xenogeneic proteins or organs suitable in xenotransplantology, or to create cell (gene) therapy foundations for a number of serious monogenic diseases that induce heritable (congenital) developmental anomalies, is perceived as a service to humanity.
6

Production of pigs used in xenotransplantation

61%
Jura J., Slomski R., Smorag Z., Gajda B., Wieczorek J., Lipinski D., Kalak R., Juzwa W., Zbyland J.
Biotechnologia
|
2006
|
issue 1
151-158
EN
There are four main trends in the use of transgenic animals. One of the most interesting is the use of transgenic animals as the donors of tissue or organs suitable for transplantation in human ? xenotransplantation. This field of research has been undergoing intensive and increasing study during the past few years, and some encouraging progress is being made. A pig has been identified as the most suitable donor animal. The aim of the presented experiment was to produce transgenic pigs which tissues and organs could be used for the xenotransplantation needs. To target the goal, a competitive gene construct coding the same substrate as the endogenous enzyme of organ donor was introduced. In effect, transgenic boar was produced with confirmed integration of human a1,2 fucosyltransferase gene. Also, F1 generation of transgenic pigs was generated to preserve ongoing needs of preliminary research of xenotransplantation project.
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