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C-banded karyotypes of some dragonfly species from Russia.

100%

Perepelov E. A., Bugrov A. G., Warchalowska-Sliwa E.

Folia Biologica

1998

vol. 46

137-142

The C-stained karyotypes of Calopteryx splendens (Harris, 1782) (2n%=25, X0, m), Aeschna viridis Eversmann, 1836 (2n%=26, neo-XY, m), Ophiogomphus cecilia (Fourcroy, 1785) (2n%=23, X0), Cordulia aenea (Linnaeus, 1758) (2n%=25, X0), Libellula depressa Linnaeus, 1758 (2n%=25, X0, m), Libellula quadrimaculata Linnaeus, 1758 (2n%=25, X0, m), Orthetrum albistylum Selys, 1848 (2n%=25, X0, m), Orthetrum brunneum (Fonscolombe, 1837) (2n%=25, X0, m) and Sympetrum pedemontanum (Allioni, 1766) (2n%=25, X0, m) from Siberia and the Northern Caucasus have been analysed. All the studied species possess C-bands at both the ends of autosomes, all Libellulinae have an intercalar C-block at largest autosome. C. aenea has the subterminal blocks near the terminal ones. The X is heterochromatic for its entire length in vast majority of species, the original X-part of the neo-XY chromosome in Ae. viridis is also entirely heterochromatic. L. depressa and C. splendens possess the euchromatic X with large terminal C-blocks.

Is the recently discovered EDA gene associated with anhidrotic ectodermal dysplasia?

100%

Kobielak K., Kobielak A., Trzeciak W. H.

vol. 38

issue 3

343-357

The evidence from literature strongly suggests that Christ Siemens Touraine (CST) syndrome is associated with mutations of the newly discovered EDA gene. The gene is situated on the long arm of the X chromosome (Xq12.2 q13.1) and contains two exons separated by a 200 kbp intron. The 5' untranslated region and most of the coding sequence are localized in exon 1, while three C terminal amino acids are encoded by exon 2. The coding sequence was interrupted by translocations in three affected females: t(X;1), t(X;12), t(X;9), and submicroscopic deletions of the EDA gene were found in five males with CST syndrome, and point mutations were discovered in exon 1 in nine other patients. Northern blot analysis and in situ hybridization studies revealed that the EDA gene was expressed in the foetus, and postnatally in a specific type of skin cell and that the expression was limited to cells of ectodermal origin. A predicted protein product of the EDA gene contains 135 to 140 amino acids, organized in three distinct domains and may belong to class II transmembrane receptors.

DNA methylation analysis of a de novo balanced X;13 translocation in a girl with abnormal phenotype: evidence for functional duplication of the whole short arm of the X chromosome

100%

Myszka A., Karpinski P., Makowska I., Lassota M., Przelozna B., Slezak R., Sasiadek M. M.

vol. 51

issue 3

331-335

We report on a 13-month-old girl showing dysmorphic features and a delay in psychomotor development. She was diagnosed with a balanced de novo translocation 46,X,t(X;13)(p11.2;p13) and non-random inactivation of the X chromosome. FISH analysis, employing the X chromosome centromere and XIST-region-specific probes, showed that the XIST locus was not involved in the translocation. Selective inactivation of paternal X, which was involved in translocation, was revealed by the HUMARA assay. The pattern of methylation of 5 genes located within Xp, which are normally silenced on an inactive X chromosome, corresponded to an active (unmethylated) X chromosome. These results revealed that in our proband the X chromosome involved in translocation (Xt) was preferentially inactivated. However, genes located on the translocated Xp did not include XIST. This resulted in functional Xp disomy, which most probably accounts for the abnormal phenotype in our patient.

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2 Journal of Applied Genetics

1 Folia Biologica

1 2010

1 1998

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1 Bugrov A. G.

1 Karpinski P.

1 Kobielak A.

1 Kobielak K.

1 Lassota M.

1 Makowska I.

1 Myszka A.

1 Perepelov E. A.

1 Przelozna B.

1 Sasiadek M. M.

1 Slezak R.

1 Trzeciak W. H.

1 Warchalowska-Sliwa E.

Search results

C-banded karyotypes of some dragonfly species from Russia.

Is the recently discovered EDA gene associated with anhidrotic ectodermal dysplasia?

DNA methylation analysis of a de novo balanced X;13 translocation in a girl with abnormal phenotype: evidence for functional duplication of the whole short arm of the X chromosome