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Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population

100%

Alharbi K., Khan I., Al-Sheikh Y., Alharbi F., Alharbi F., Al-Nbaheen M.

2014

vol. 61

issue 4

769-772

The ubiquitin-conjugating enzyme E2E 2 (UBE2E2) gene plays an important role in insulin synthesis and secretion under conditions in which stress to the endoplasmic reticulum is increased in β-cells. In this case-control study, we have selected rs7612462 polymorphism within UBE2E2 gene to identify in a Saudi population the type 2 diabetes mellitus (T2DM) subjects. In total, 376 subjects with T2DM and 380 controls were enrolled in this study. We have collected 5 mL of peripheral blood from each participant for biochemical and molecular analyses. PCR-RFLP was used to generate genotypes at rs7612462 in all of the study subjects. Clinical data and anthropometric measurements of the patients were significantly different from those of the controls (p<0.05). All of the subjects used in this study were non-obese (25

Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han Population

88%

Kazakova E., Wu Y., Zhou Z., Chen M., Wang T., Tong H., Zhuang T., Sun L., Qiao H.

2015

vol. 62

issue 2

241-245

UBE2E2 encodes ubiquitin-conjugating enzyme E2E2, which plays an important role in the synthesis and secretion of insulin. Two previous studies indicated that SNPs in UBE2E2 were associated with risk for type 2 diabetes mellitus (T2DM) in the Japanese and Korean populations, respectively. We examined the association of one SNP in this gene, rs7612463, with the risk of T2DM in 1957 Han participants in northeastern China, using an SNPscanTM Kit. rs7612463 genotype was significantly associated with risk for T2DM under various genetic models, including an additive model (P = 0.004), a dominant model (P = 0.024), and a recessive model (P = 0.008). The AA genotype was associated with a significantly decreased risk for T2DM (P = 0.004, OR = 0.513, 95% CI = 0.325-0.810) after adjustment for age, gender, and BMI. The heterozygous genotype, AC, was associated with increased risk for total cholesterol (mmol l-1; P = 0.031) and triglycerides (mmol l-1; P = 0.039) in control individuals. Our results show that rs7612463 is associated with T2DM, with homozygotes of the AA genotype at decreased risk for T2DM in the Chinese population. Additionally, heterozygotes may have decreased risk of T2DM due to insulin resistance.

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2 Acta Biochimica Polonica

1 2015

1 2014

1 Al-Nbaheen M.

1 Al-Sheikh Y.

1 Alharbi F.

1 Alharbi K.

1 Chen M.

1 Kazakova E.

1 Khan I.

1 Qiao H.

1 Sun L.

1 Tong H.

1 Wang T.

1 Wu Y.

1 Zhou Z.

1 Zhuang T.

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Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population

Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han Population