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1

Segregation of transferrin alleles in a flock of long-wool sheep

100%
Kmiec M.
Genetica Polonica
|
1993
|
vol. 34
|
issue 3
273-285
EN
Studies on in the flock of from the State Animal Breeding Station in Bobrowniki were carried out. Genetic structure, of the population consisting of 6832 animals (171 rams, 3050 ewes and 3611 lambs) was examined. Inheritance of was traced and it is postulated to apply studies on transferrin polymorphism for parentage cintrol. In the studied sheep population the most frequent were alleles and BC, BD, CD and BB phenotypes. An analysis of transferrin alleles transfer from parents to their offspring in some cases showed significant divergence between the observed and expected numbers of offspring carrying particular genes. That concerned the phenotype AB in rams as well as AD and BE phenotypes in ewes. A theoretical probability of parentage exclusion in the examined stud of long-wool sheep estimated on the basis of the frequency of genes determining transferrin phenotypes was 43.18%.
2

An overall view of the process of the regulation of human iron metabolism

100%
Formanowicz D., Formanowicz P.
Biotechnologia
|
2011
|
issue 2
193-207
EN
Iron is a key component of many reactions in the human body, and by virtue of its ability to accept and donate electrons, it is required for a variety of normal cellular functions and is vital for proper growth and development. However, natural iron is rather insoluble and excess of iron is harmful since it can catalyze the formation of oxygen radicals. Fortunately, there are also mechanisms for protecting human body from excess 'free' iron. This is particularly important, given the fact that humans have very limited capacity to excrete iron. Therefore, cells have developed mechanisms to improve the solubility of iron to control intracellular iron concentrations at the point of iron absorption in the small intestine and other tissues. Since the described process is highly complex, a profound understanding of all the relationships occurring among its components is possible when a systems approach is applied to its analysis.
3

Relationship between transferrin asnd globulin antigen polymorphism and sheep resistance to mastitis

88%
Charon K., Lipecka C., Siudek T., Swiderek P., Skiba E.
Journal of Applied Genetics
|
1996
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vol. 37
|
issue 2
161-172
EN
The effect of transferrin genotypes and genes and globulin antigens on sheep resistance/susceptibility to mastitis was analysed.The udder health conditoin was diagnosed on the basis of the somatic cell count in 1 ml milk and result of bacteriological tests.It was found that sheep with transferrin genotype AC, AD and CC were characterised by a better health of the mammary gland than the remaining ewes.Among 9 transferrin alleles observed in the examined sheep, only the presence of transferrin I allele in the ewes genotype was connected with the somatic cell count below the mean value of this traint.The presence of transferrin A allela in sheep's genotype was connected with a small infection of milk with mastitis pathogens.The serum globulin antigens analysed did not significantly affect the somatic cell acount in the milk of the examined ewes.However, the antigens A2, NS1 (antigens of beta-globulin) and GB2 (antigen of class IgG immunoglobulins) as well as the globulin antigen A6 and GA1 antigen of class IgG immunoglobulins showed to have a significant effect on the level of sheep milk infection.
4

Glycoforms of six serum glycoproteins in a patient with congenital disorder of glycosylation type I

63%
Ferens-Sieczkowska M., Zwierz K., Midro A., Katnik-Prastowska I.
Archivum Immunologiae et Therapiae Experimentalis
|
2002
|
vol. 50
|
issue 1
67-74
EN
In this paper the occurrence and relative content of defectively glycosylated serum glycoforms in transferrin (Tf), 1-acid glycoprotein (AGP), haptoglobin (Hp), 1-antitrypsin (1-AT), 2-macroglobulin (2-MG) and ceruloplasmin (Cpl) in the serum of a patient with congenital disorder of glycosylation type I are reported. Blood samples were taken when the patient was 14 years old and then after a one-year interval. The patterns of glycoforms in both samples were compared. In 4 out of 6 examined glycoproteins, glycoforms lacking one and two oligosaccharide chains occurred. ?Underglycosylated? glycoforms of 2-MG and Cpl were not clearly detectable. Tf was shown to be affected with this defect to a higher extent than other glycoproteins, containing only 30% properly glycosylated molecules and also as much as 30% of the molecules lacking two glycan units. In Hp and 1-AT the proportions of properly and defectively glycosylated forms were similar. This properly glycosylated form comprised 47% of the Hp and 51?55% of the 1-AT molecules. As in AGP and Tf, about 30% the of molecules lacked one glycan unit. Twenty-one percent of the Hp molecules were devoid of two glycans, and this amount slightly increased in the course of the year. In 1-AT, 19 and 17% of the molecules lacked two glycans in both samples, respectively. Only in AGP we did find a substantial difference between the two blood samples. In the course of the year, the amount of the form lacking 2-chains decreased from 12 to 3%, resulting in a simultaneous increase in the forms lacking one chain and the properly glycosylated. Our work also indicates, that applying a simple method of biochemical analysis such as SDS-PAGE/Western-blotting could be helpful in preliminary diagnosis and could improve the identification of congenital disorders of glycosylation.
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