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microRNA application to livestock

100%
Lisowski P., Goscik J., Zwierzchowski L.
Biotechnologia
|
2010
|
issue 3
115-125
EN
Post-transcriptional gene regulation guided by microRNAs has emerged as one of the major gene regulatory mechanisms in higher eukaryotes. microRNAs regulate gene translation through the recognition of complementary sequences between microRNAs and their target genes. Recent studies in livestock have revealed that many microRNAs are species- and tissue-specic, indicating that microRNAs play important roles in essential physiological processes in livestock, such as metabolism, and muscle and organ development. It is anticipated that many microRNAs will be linked to phenotypic differences or quantitative trait variations of livestock. The role of microRNA in developmental decisions that affect animal biology is of significant interest, yet the current literature on livestock models is limited. In this review, we summarize the current microRNA studies undertaken in livestock.
2

Noncoding RNA transcriptomics

88%
Zywicki M.
Biotechnologia
|
2010
|
issue 3
191-201
EN
The growing amount of knowledge about noncoding RNA molecules indicates their major role in regulation of cellular processes. For a long time there was no method which would allow for massive identification and analysis of such kind of transcripts. In recent years, the ongoing explosion of high throughput sequencing methods allowed a deep look into the transcriptome via the cDNA library analysis techniques, like RNA-seq. Since most of such protocols has been aimed for mRNA expression profiling, their adaptation for noncoding RNA research is necessary. It is mainly caused by differences in structure and properties of those two gropus of transcripts. In this article, the main difficulties and challenges in investigation of noncoding RNAs with high throughput sequencing methods will be discussed.
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