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Neuropathological changes in resected temporal lobe of patients with cryptogenic epilepsy

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Kroh H., Taraszewska A., Ruzikowski E., Bidzinski J., Mossakowski M. J.

Neuropatologia Polska

1992

vol. 30

issue 2

133-146

The study was performed on cerebral tissue resected during temporal lobectomy in 16 patients whose long-standing cryptogenic epilepsy did not submit to anticonvulsive drugs. Cases presenting definite etiological factors such as CNS trauma, infection or neoplasm were excluded. Neuropathological investigations disclosed microangiomas and focal vascular malformations in the meninges and tissue in 7 patients. Neuronal heterotopias in the white matter and of the white matter in the cortex were observed in 3 cases, Main cortical changes were: neuronal loss,chronic neuronal degeneration, perineuronal satellitosis, and GFAP-positive submeningeal gliosis, especially at the bottom of sulci, perivascular gliosis and laminar or diffuse gliosis. the changes in the hippocamus were most enhanced in the end-plate and in the sector H3 of the pyramidal layer. Astrocytic gliosis in the white matter presented distinct GFAP and S-100 immunostaining; the latter involved in some cases a wider area than the GFAP reaction. The above named changes are analysed with regard to the presumed epileptogenic factors and to the postepileptic damage.

Disturbances in time limited storage of sensory information after right temporal lobectomy

100%

Szatkowska I., Szmanska O., Bednarek D., Skowronska R., Grabowska A.

Acta Neurobiologiae Experimentalis

1996

vol. 56

issue 1

259-262

Our previous study performed on subjects with no brain damage suggested that processes involved in the storage of sensory information are lateralized to the right hemisphere. The present research aimed at verifying this hypothesis by studying the effect of unilateral temporal lobe lesion on performance in a sensory information storage test. Seventeen patients who had undergone a unilateral temporal lobectomy for the relief of intractable epilepsy (8 subjects - left hemisphere damage, 9 subjects - right hemisphere damage) and 11 normal control subjects with no brain damage were tested. The subjects were presented with geometrical Vanderplas type figures exposed in pairs, each for 100 ms, one afther another, with short (50 ms and 500 ms) and long (3,000 ms) interstimulus intervals (ISI). The task of the subjects was to judge whether the second stimulus was the same as, smaller or bigger then the first one. The first stimulus in each pair was exposed unilaterally, randomly in the left (LVT) or right (RVT) visual field, and the second one in the center of the screen. In short ISI condition the RH-damaged group performed worse then both the control group and the LH-damaged group. In long ISI condition the RH-damaged group did not differ from the controls .On the contrary th LH-damaged group did not differ significantly from the controls in any ISI condition. The results shows that temporal lobe structures are involved in time limited storage of sensory information. Moreover, they provide further evidence for the right-hemispheric locus of this storage.

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1 Acta Neurobiologiae Experimentalis

1 Neuropatologia Polska

1 1996

1 1992

1 Bednarek D.

1 Bidzinski J.

1 Grabowska A.

1 Kroh H.

1 Mossakowski M. J.

1 Ruzikowski E.

1 Skowronska R.

1 Szatkowska I.

1 Szmanska O.

1 Taraszewska A.

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Neuropathological changes in resected temporal lobe of patients with cryptogenic epilepsy

Disturbances in time limited storage of sensory information after right temporal lobectomy