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1

Signel pathways governing maturation and function of T-cells

100%
Matuszyk J., Strzadala L.
Postępy Higieny i Medycyny Doświadczalnej
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1997
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vol. 51
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issue 4
351-365
EN
Signals delivered through the b/gp33 (pre-TCR) and T-cell receptor ab control proliferation and differentiation of thymocytes at two distinct control points of T cell maturation. Interaction between T-cell receptor (TCR) and peptide/MHC complex induce signaling pathways leading to activation of T cell. Signal transduction involves CD3z phosphorylation by Lck tyrosine kinase and activation of ZAP-70 which regulates signaling pathways through PKC, Ca++ and Ras/Raf kinase cascade. Appropriate response of cell is preceded by integration of different signals in the nucleus.
2

The TCR/CD3 complex: molecular interactions in a changing structure

63%
Feito M. J., Jimenez-Perianez A., Ojeda G., Sanchez A., Portoles P., Rojo J. M.
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issue 4
263-272
EN
The T cell receptor-CD3 (TCR/CD3) complex is a multichain structure in charge of antigen recognition in T cells. Despite many genetic, structural, and functional data obtained in recent years, essential questions concerning the TCR/CD3 complex still remain open, including: 1) the precise number of polypeptides in each TCR/CD3 complex, their interactions and spatial arrangement; 2) the role(s) of each polypeptide in antigen recognition and/or in receptor signal transmission, and 3) the relationship between the TCR/CD3 complex and other membrane or cytoplasmic molecules involved in downstream signaling. In this work we shall review data concerning some of these issues, proposing a model of the overall structure of the TCR/CD3 complex to explain its known features.
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