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Toxicological Significance of the Occurrence of Selenium in Foods

100%
Adewale G. G., Olajide P. A., Omowumi O. S., Okunlola D. D., Taiwo A. M., Adetuyi B. O.
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vol. 44
63-88
EN
The presence of selenium (Se) in foods and the pertinent toxicological data are reviewed. In most regions of the world, the average daily intake of man is thought to be between 60 and 250 micrograms for adults and between 4 and 35 micrograms for infants. The current practice of adding selenium supplements to animal feeds may increase the selenium content of meats by up to 30%, but this does not result in a biologically meaningful increase in the selenium intake of people. Se is mostly absorbed after ingestion, according to the available metabolic data. Up to 50% of it is eliminated in the urine, while the remaining percentage builds up primarily in the liver and kidneys. Recent epidemiological and animal studies show that Se is not a carcinogen, and in some cases may have anti-cancer properties. Neither the essentiality for man, nor the no-effect level of Se have been established.
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The effects of vitamin E and selenium on blood flow to experimental skin burns in rats using the 133Xe clearance technique

88%
Varoglu E., Seven B., Gumustekin K., Aktas O., Sahin A., Dane S.
Open Medicine
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2010
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vol. 5
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issue 2
219-223
EN
The aim of the present experimental study was to determine and to compare the effects of vitamin E and of selenium on the blood flow to a wound region in rats, using the xenon-133 (133Xe) clearance technique. Burn wounds were made on the right thighs of rats followed by oral administration of vitamin E or selenium for a period of 10 days. The effect of vitamin E and of selenium individually on blood flow in the wound region was assessed before and after oral administration using the 133Xe clearance technique. Both vitamin E and selenium significantly increased the blood flow in the wound region (P<0.05). Our results in rats suggest that both vitamin E and selenium have beneficial effects on the skin wound healing process by increasing the skin blood flow.
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Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats

88%
Sochor J., Pohanka M., Ruttkay-Nedecky B., Zitka O., Hynek D., Mares P., Zeman L., Adam V., Kizek R.
Open Chemistry
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2012
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vol. 10
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issue 5
1442-1451
EN
Selenium is a micronutrient, localized in the active sites of enzymes such as glutathione peroxidase and thioredoxin reductase, and participating together with these enzymes in an antioxidant defence system of organisms against free radicals. Administration of selenium is necessary for maintaining oxidative homeostasis. The present experiment is aimed at investigation of selenium impact on basal metabolic processes and selected antioxidants in a Wistar rat model, fed selenium in organic and inorganic forms. Liver, kidney, brain and muscle were sampled during a month-long feeding with four different doses of selenium (0.075 mg or 1.5 mg of inorganic and/or organic selenium per kg of feed). We found a significant reduction in glutathione level in liver tissue regardless of the form of the administered selenium. On the other hand, selenium caused a decreased glutathione reductase level in the liver and metallothionein level in the liver, kidney and muscle. [...]
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