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Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis(2- and 4-formylaryloxymethyl)pyridines.

100%

Kuz'min V. E., Lozitsky V. P., Kamalov G. L., Lozitskaya R. N., Zheltvay A. I., Fedtchouk A. S., Kryzhanovsky D. N.

2000

vol. 47

issue 3

867-875

Quantitative estimation of the structure - anticancer activity relationship in a series of macrocyclic Schiff bases of 2,6-bis(formylaryloxymethyl)pyridines was carried out by the topological approach. Correlation equations describing the relationship between the anticancer activity and structural parameters of the molecules studied and descriptors characterizing their structure were obtained on the basis of in vitro screening data. The influence of structure of the investigated substances as reflected by the parameters studied on the anticancer activity, was established.

Stability prediction of Cu2+, Ni2+ and Zn2+ N-salicylidene-aminoacidato complexes by models based on connectivity index 3 χ v

80%

Miličević A., Raos N.

Open Chemistry

2014

vol. 12

issue 1

74-79

This paper presents models for the estimation of stability constants (K 1 and β 2) of nickel(II), copper(II) and zinc(II) mono- and bis-complexes with 5 Schiff bases (salicylideneglycine, salicylidenealanine, salicylideneserine, salicylidenephenylalanine, and salicylidenetyrosine). The models were based on the molecular-graph theory and valence molecular connectivity index of the 3rd order, 3χv , derived from it. Univariate linear models were developed for each metal separately, while in the common models for two and three metals, the indicator variable, In, was introduced. The standard error of models for the log K 1 constant was less than 0.12, while for log β 2 models, the S.E. did not exceed 0.14. [...]

Simple generation of neutral bimetallic aluminium and zinc alkyls Schiff bases bridged by a central resorcinol moiety

70%

Aazam E., Coles M.

Aluminium and zinc complexes bearing the N,O-chelating Schiff base ligand 4,6-bis-1-(2-(dimethylamino)ethylimino)ethyl)benzene-1,3-diol, (C6H2(OH)2(NCH2CH2NMe2)2) (1a), have been synthesized. Bimetallic aluminium and zinc alkyl complexes (2a–4a) were prepared by treatment of the hexadentate 1a with the appropriate amount of AlMe3, ZnMe2 and ZnEt2, respectively. 2a has been characterized crystallographically, it lies on a crystallographic two-fold rotation axis and each aluminium centre adopts a five coordinate geometry. Complex 2a was tested as a catalyst in the ring-opening polymerisation of ɛ-caprolactone. We describe here the synthesis of two neutral ligands (1a and (C6H2(OH)2(C6H5NH2) (C=O(CH3)) (1b)) and demonstrate their application in the synthesis of molecular aluminium and zinc derivatives.

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2 Open Chemistry

1 Acta Biochimica Polonica

1 2014

1 2010

1 2000

1 Aazam E.

1 Coles M.

1 Fedtchouk A. S.

1 Kamalov G. L.

1 Kryzhanovsky D. N.

1 Kuz'min V. E.

1 Lozitskaya R. N.

1 Lozitsky V. P.

1 Miličević A.

1 Raos N.

1 Zheltvay A. I.

Search results

Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis(2- and 4-formylaryloxymethyl)pyridines.

Stability prediction of Cu2+, Ni2+ and Zn2+ N-salicylidene-aminoacidato complexes by models based on connectivity index 3 χ v

Simple generation of neutral bimetallic aluminium and zinc alkyls Schiff bases bridged by a central resorcinol moiety