Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 1

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  SYNAPTIC DRIVE
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

A single compartment neuron model with activity-dependent conductances during NMDA induced activity

100%
Baszczak M., Kasicki S.
Acta Neurobiologiae Experimentalis
|
2005
|
vol. 65
|
issue 2
183-190
EN
In most neuron models the values of maximal conductances of membrane ionic currents are fixed. In our paper we investigate spiking activity of the neuron model activated tonically by NMDA synapse, when the membrane ionic currents are dynamically dependent on calcium concentration, as in a model by Abbott and coauthors (1993). A spiking neuron model (in Matlab/Simulink environment) is based on the properties of lamprey spinal neurons. The basic neuron is a one-compartment model with voltage-gated Na+, K+, Ca2+, KCa+ channels. The Na+ and K+ currents are described with the dynamic equations of Hodkin-Huxley model (Hodgkin and Huxley 1952). The Ca2+ and KCa+ channels are modeled using description of calcium dynamic introduced by Ekeberg and coauthors (1991). The model was tonically activated by NMDA synapse, described by a kinetic model of synaptic transmission. We analyzed the activity of this model and showed that when only one of conductances is calcium-dependent, the cell is not able to react to and recover from external perturbations.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.