Search results

Search:
in the keywords: SUDEP

Sort By:

Limit search:

Sudden Unexpected Death In Epilepsy (SUDEP) – an update

100%

Majkowski J.

Journal of Epileptology

2013

vol. 21

issue 1

37-54

Introduction. SUDEP is not so rare event, unexplained, underused and underestimated. Its awareness has recently contributed to a number of initiatives for global action and clinical and experimental research. Aim. To undertake a literature review so as to update various aspects of SUDEP: pathophysiological mechanisms, potential markers for autonomic dysfunctions and risk factors, AEDs effects, non-AED management options, forensic/autopsy, patient-physician communications in patients with SUDEP risk. Method. A literature review, up to Nov. 2012, was conducted using PubMed-Medline for SUDEP, no indexed citation and relevant papers. Review. Interactions between the central and peripheral origin of cardiac and respiratory dysfunctions, triggered by epileptiform discharges in the cortical representation of the autonomic functions, may lead to SUDEP during simple partial autonomic seizures - even without other components of a seizure. A number of potential biomarkers of autonomic dysfunctions and risk of SUDEP are identified and proposed to use in its prevention: heart rate variability, long and short QT, arrhythmias, asystole, oxygen desaturation, apneas, hypoxia, postictal EEG suppression, circadian seizure pattern. Conclusions. Risk factors for SUDEP, AEDs effects, non-AED management of preventive options and forensic autopsy in diagnosis of SUDEP are discussed. Periictal long term video EEG, ECG and oxygen saturation monitoring may contribute to better understanding of SUDEP mechanisms and eventually to its prevention. SUDEP occurs as fatal coexistence of several predisposing risk factors. Diagnosis of SUDEP is underestimated and underused. In patient with high risk factors for SUDEP, in particular, with AED noncompliance, prognosis of epilepsy should be discussed with patient.

Nagły zgon sercowy a nagły zgon u chorych na padaczkę

100%

Mańka-Gaca I., Łabuz-Roszak B.

issue 73

60-64

Sudden unexpected death in people previously considered healthy represents an important challenge for modern medicine. The causes of this phenomenon are constantly being sought and attempts are being made to understand its pathomechanism. Among those at great risk are patients with epilepsy. Every unexpected death in a patient with epilepsy who was generally healthy in normal life activity and no other cause of the death was identified, is considered sudden unexpected death in epilepsy (SUDEP). Despite the difficulty in predicting sudden death, special attention should be paid to those at high risk, especially affected by cardiovascular diseases and epilepsy.

Nagłe niespodziewane zgony u osób dotychczas uważanych za zdrowe stanowią istotne wyzwanie dla współczesnej medycyny. Wciąż poszukuje się przyczyn tego zjawiska i próbuje poznać jego patomechanizm. Wśród osób szczególnie narażonych znajdują się osoby chorujące na padaczkę. Każdy niespodziewany zgon u chorego na padaczkę, którego ogólny stan zdrowia był dobry, aktywność życiowa normalna i u którego nie znaleziono innej przyczyny chorobowej tego zdarzenia, określa się terminem nagłej niespodziewanej śmierci u chorych na padaczkę (sudden unexpected death in epilepsy – SUDEP). Pomimo trudności w przewidywaniu nagłych zgonów szczególnym nadzorem należy objąć osoby z grupy podwyższonego ryzyka, do których niewątpliwie należą chorzy z chorobami układu sercowo-naczyniowego oraz z padaczką.

Refine search results

1 Annales Academiae Medicae Silesiensis

1 Journal of Epileptology

1 2019

1 2013

1 Majkowski J.

1 Mańka-Gaca I.

1 Łabuz-Roszak B.

Search results

Sudden Unexpected Death In Epilepsy (SUDEP) – an update

Nagły zgon sercowy a nagły zgon u chorych na padaczkę