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1

Do Langerhans cells play a role in vulvar epithelium resistance to squamous cell carcinoma?

100%
Rotsztejn H., Trznadel-Budzko E., Jesionek-Kupnicka D.
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2007
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vol. 55
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issue 2
127-130
EN
Introduction: Langerhans cells (LCs) are a very important part of the skin immune system. Materials and Methods: Skin biopsies taken from 13 women after the removal of vulvar squamous cell carcinoma (SCC) who had not been treated earlier for any vulvar diseases were investigated. The control group consisted of 12 women who underwent a plastic surgical operation of the vulva region. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded tissues samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra). Results: This study showed a large decrease in LCs in vulvar SCC. Conclusions: It is postulated that the reduction in the number of LCs may be one of the reasons for a higher tendency of carcinogenesis in the vulvar region. Their role as a main element of the skin immune system in the initiation of this process needs further investigation. It is possible that research on LCs in the skin will cast a new light on their role and even contribute to the prophylaxis and treatment of skin and mucosa carcinomas.
2

MicroRNA in pathogenesis of head and neck squamous cell carcinoma

100%
Szaumkessel M., Szyfter K.
Biotechnologia
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2010
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issue 3
64-74
EN
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer in regard of both incidence and poor effect of treatment therapies, manifested in low cure rates (5-year survival rate ? 50%). The molecular heterogeneity found in HNSCC is the main reason why the already published data has not been sufficient to develop reliable prognostic tests and efficient therapies. A novel group of small non-coding RNA molecules (microRNA or miRNA) has been identified and proved to be strongly involved in cancer. However, the existing data does not specifically address microRNA involvement in HNSCC development and progression. This report summarizes the state-of-art concerning miRNA research in head and neck cancer and provides a list of miRNAs potentially involved in HNSCC pathogenesis.
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