Search results

Search:
in the keywords: SPONGIFORM ENCEPHALOPATHY

Sort By:

Limit search:

100%

Piasecki E.

Postępy Higieny i Medycyny Doświadczalnej

1993

vol. 47

issue 2

85-99

are proteinaceous infection particles. They are probably devoid of nucleic acid. (PrP) is encoded by the normal cellular gene. of prion protein has different conformation than the normal PrP protein. The exact nature of the posttranslational modification of prion protein is unknown. This modification may be caused by infection with prions infectious disease or occures spontaneously sporadic disease. Some mutations in PrP gene results in the production of pathological protein familial disease.

Proliferation of mesaxons in the optic nerve of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease

100%

Walis A., Liberski P. P.

Acta Neurobiologiae Experimentalis

1999

vol. 59

issue 3

177-180

The Echigo-1 strain of CJD was isolated by Mori and colleagues from a case of 33-years-old female with a panencephalopathic type of CJD. An incubation period following intracerebral inoculation of hamsters with 10 % cleared suspension of the Echigo -1-affected brain was approximately six months. We report here ultrastructural changes in the optic nerves. Vacuoles developed within myelinated axons: within axoplasm or within the myelin sheath and these were accompanied by exuberant reaction of macrophages and hypertrophied astrocytes. Axons underwent Wallerian degeneration and dystrophic neurites were also seen. Most important, we observed proliferation of inner mesaxons. Cross-sectional profiles of innumerable myelinated fibers contained membranous organelles which were continuous with the inner lamellae of the oligodendroglial cells. These unusual proliferations of inner mesaxons formed whorls and elaborated loops. In some axons, proliferation was so severe that loops of mesaxon filled the whole cross-section of the axon. Occasionally, we observed intrusion of the membranous tongue of the inner mesaxon into axoplasm.

Refine search results

1 Acta Neurobiologiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

1 1999

1 1993

1 Liberski P. P.

1 Piasecki E.

1 Walis A.

Search results

Proliferation of mesaxons in the optic nerve of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease