Search results

Search:
in the keywords: SINGLE-NUCLEOTIDE POLYMORPHISM

Sort By:

Limit search:

Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis

100%

Chen S. Y., Wan L., Huang C. M., Huang Y. C., Sheu J. J. C., Lin Y. J., Liu S. P., Lan Y. C., Lai C. H., Lin C. W., Tsai C. H., Tsai F. J.

vol. 51

issue 4

519-521

Rheumatoid arthritis (RA) is a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. A previous study indicated that a DNA repair system was involved in the development of RA. In this study, we investigated the association of four N-methylpurine-DNA glycosylase (MPG) gene polymorphisms (rs3176364, rs710079, rs2858056, and rs2541632) with susceptibility to RA in 384 Taiwanese individuals (192 RA patients and 192 control subjects). Our data show a statistically significant difference in genotype frequency distributions at rs710079 and rs2858056 SNPs between RA patients and control groups (P = 0.040 and 0.029, respectively). Our data also indicated that individuals with the GG genotype at rs2858056 SNP may have a higher risk of developing RA. In addition, compared with the haplotype frequencies between case and control groups, individuals with the GCGC haplotype appeared to be at a greater risk of RA progression (P = 0.003, OR = 1.75; 95% CI = 1.20-1.55). Our results suggest that rs710079 and rs2858056 polymorphisms and the GCGC haplotype in the MPG gene are associated with the risk of RA progression, and thus may be used as molecular markers of RA if they are confirmed by further research.

A novel single-nucleotide polymorphism of the visfatin gene and its associations with performance traits in the chicken

100%

Han R.-L., Lan X.-Y., Zhang L.-Z., Ren G., Jing Y.-J., Li M.-J., Zhang B., Zhao M., Guo Y.-K., Kang X.-T., Chen H.

vol. 51

issue 1

59-65

Visfatin is a peptide that is predominantly expressed in visceral adipose tissue and is hypothesized to be related to obesity and insulin resistance. In this study, a novel silent single-nucleotide polymorphism (SNP) was found in exon 7 of the chicken visfatin gene (also known as PBEF1) by single-stranded conformation polymorphism (SSCP) and DNA sequencing. In total, 836 chickens forming an F2 resource population of Gushi chicken crossed with Anka broiler were genotyped by XbaI forced RFLP, and the associations of this polymorphism with chicken growth, carcass characteristics, and meat quality were analyzed. Significant associations were found between the polymorphism and 4-week body weight (BW4), 6-week body weight (BW6), 4-week body slanting length (BSL4), fat bandwidth (FBW), breast muscle water loss rate (BWLR) and breast muscle fiber density (BFD) (P < 0.05), as well as 4-week breastbone length (BBL4) (P < 0.01). These observations suggested that the polymorphism in exon7 of the visfatin gene had significant effects on the early growth traits of chicken.

Refine search results

2 Journal of Applied Genetics

2 2010

1 Chen H.

1 Chen S. Y.

1 Guo Y.-K.

1 Han R.-L.

1 Huang C. M.

1 Huang Y. C.

1 Jing Y.-J.

1 Kang X.-T.

1 Lai C. H.

1 Lan X.-Y.

1 Lan Y. C.

1 Li M.-J.

1 Lin C. W.

1 Lin Y. J.

1 Liu S. P.

1 Ren G.

1 Sheu J. J. C.

1 Tsai C. H.

1 Tsai F. J.

1 Wan L.

1 Zhang B.

1 Zhang L.-Z.

1 Zhao M.

Search results

Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis

A novel single-nucleotide polymorphism of the visfatin gene and its associations with performance traits in the chicken