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EN
Erythrocyte destruction in laminar (Couette) flow was investigated. Critical values of the shear stress for ovine erythrocytes from two donors were determined. Large individual differences between erythrocytes from the two donors suggest that individual determination of shear stress resistance for each donor is necessary, and that the determination of shear stress resistance might be of diagnostic value.
EN
One of the major hemodynamic forces acting on blood vessels is shear stress, which is, the friction force between the endothelial cell surface and flowing blood. Arterial shear stress within physiologic range (15-70 dyne/cm2) induces endothelial quiescence and an atheroprotective gene expression profile. Low shear stress (< 4 dyne/cm2 ) stimulates atherogenic phenotype, whereas, high shear stress (>70 dyne/cm2 ) induce prothrombotic state.
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