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Severe aplastic anemia in a patient with rheumatoid arthritis after introduction of etanercept

100%
Horai Y., Miyamura T., Shimada K., Ishida M., Takahama S., Minami R., Yamamoto M., Suematsu E.
Open Medicine
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2012
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vol. 7
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issue 5
650-654
EN
A 73-year-old female, diagnosed with rheumatoid arthritis (RA), complicated with severe levels of joint destruction, started etanercept (ETN) because of high persistent RA disease activity. Although her articular symptoms dramatically improved, she developed marked pancytopenia after the introduction of ETN. Bone marrow aspirate specimen revealed hypocellular marrow in three hematopoietic series without atypical findings, which was compatible with aplastic anemia (AA). This is a rare case of severe pancytopenia due to AA presumably induced by ETN.
2
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Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with rheumatoid arthritis

100%
Peng Y.-F., Cao L., Zeng Y.-H., Zhang Z.-X., Chen D., Zhang Q., Zhu Y.-S.
Open Medicine
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2014
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vol. 10
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issue 1
EN
Objectives: It has been well documented that the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) are associated with outcomes for patients with gastric cancer, non-small cell lung cancer and acute heart failure. Inflammation may be the hidden factor that explains the correlation between NLP, PLR, and these diseases. However, to date, the data concerning NLR, PLR, and its association with inflammation are lacking in patients with rheumatoid arthritis (RA), thus, our aim to discuss whether NLR and PLR are associated with RA. Methods: Patients with RA and healthy individuals were included according to the determined criteria, and laboratory indicators were measured. Results: PLR and NLR were significantly higher in RA patients compared with healthy controls (3.20±2.06 vs. 1.56±0.47, P<0.01; 192.85±101.78 vs. 103.49±28.68, P<0.01). When leukocytes, neutrophil percentage, neutrophil, lymphocyte, platelet, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) were considered as confounders (crude model), our results indicated that ESR and RF were correlated to RA. Of note, ESR, RF, and PLR were associated with RA after further adjustment based on crude model for PLR and NLR. Receiver operating characteristic (ROC) curves analysis showed that PLR values higher than >115.7 evaluated RA with a sensitivity of 82.5%, a specificity of 74.8% and area under the curve ( AUC ) of 0.847. Conclusions:Our results suggest that PLR is associated with RA, and PLR may be an underlying indicator indicating the chronic subclinical inflammation in patients with RA.
3
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Visfatin: a new player in rheumatic diseases

88%
Gómez R., Suarez A., Villalvilla A., Herrero-Beaumont G., Largo R., Young D. A.
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vol. 1
10-15
EN
During the last 50 years the number of overweight and obese people in developed countries has increased dramatically. The consequences of this excessive fat accumulation have been associated with a multitude of comorbidities, mainly related to the cardiovascular system and glucose and lipid metabolism. However, obesity also has an impact on other diseases, as an enhancer of certain pathological aspects or as a susceptibility factor, including certain rheumatic diseases such as rheumatoid arthritis (RA), osteoarthritis (OA) and systemic lupus erythematosus (SLE). The link between obesity and these rheumatic diseases has been purported to be via the action of metabolic factors produced by adipose tissue, adipokines. Among these adipokines are leptin and adiponectin, which have been extensively studied. Our knowledge of the role of other relevant newer adipokines, such as visfatin, in the arthritides is rapidly growing. Therefore, in this review our aim is to summarize the current literature regarding the association between visfatin and the most relevant rheumatic diseases.
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ASSESSMENT OF THE KALTENBORN & EVJENTH MANUAL THERAPY IN IMPROVING THE CONDITION OF HANDS WITH RHEUMATOID ARTHRITIS

75%
MAŃKO G., MAZUR-BIAŁY A. I., DEMKIEWICZ D., POKORSKA J.
Medicina Internacia Revuo
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2013
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vol. 25
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issue 101
145-155
EN
Rheumatoid arthritis (RA) is an autoimmune disease present among close to 0.3 – 1.5% of the population, mainly women. The disease usually starts in the hand joints, which are gradually deformed, quickly impairing the normal functioning of the patients. The pain, loss of the smooth movements and the deformation of hands influence the impairment of everyday activities and decrease the quality of the patients’ lives. The goal of this work is the assessment of the effectiveness of manual therapy in alleviating the symptoms of the developing RA in the area of the hand joints, especially verifying whether the manual therapy decreases the experienced pain, improves the manual dexterity, as well as verifying how the therapy influences the everyday activities and the quality of life of the examined patients in the emotional as well as in the social and professional aspects. There were 25 women with diagnosed RA taking part in the study, which underwent a 2-week manual therapy. The effectiveness of the therapy was assessed with help of hand movement tests and questionnaires, including the modified Laitinen’s scale and the FRI test. The results showed, that the use of the manual therapy significantly improved the quality of the examined women’s lives. Manual therapy may be an effective therapeutic method for RA patients.
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