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Bdellovibrio and like organisms: The much-anticipated “magic bullet”

100%
Ebana R. U. B., Edet U. O., Anosike I. K., Etok C. A.
World News of Natural Sciences
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2019
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vol. 23
233-249
EN
With advances in next generation sequencing and microscopy, a clearer picture is beginning to emerge about the predatory properties of Bdellovibrio and like organisms (BALOs). BALOs are Gram negative microorganisms which are natural predators of other Gram-negative microorganisms, especially those associated with diseases in humans and animals. One of the limitations of BALOs is their inability to prey upon Gram-positive organisms that cause the bulk of human diseases. The global spread of antibiotics resistance to almost every group of antibiotics, and the paucity of newer antibiotics since 1970s is very worrisome. The ability of BALOs to decimate pathogen populations principally those carrying multidrug résistance genes coupled with the increasing rate of antibiotics resistance, has made them an attractive option as biocontrol agents. With the absence of resistance to BALOs, these much anticipated “magic bullets” will certainly find more and more applications in health, agriculture, medicine and environment in the nearest future.
2
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Examination of Electrical Resistance of Carburizers Used for Cast Iron Production

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Książek D., Kuś R., Koza M., Bieroński M., Krasa O.
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3
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High-residual platelet activity despite dual antiplatelet treatment associated with subacute stent thrombosis

100%
Malý M., Hadačová I., Hájek P., Zemánek D., Veselka J.
Open Medicine
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2009
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vol. 4
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issue 1
119-124
EN
High-residual platelet activity despite the dual antiplatelet treatment with aspirin and clopidogrel is associated with major adverse cardiac events, including stent thrombosis. Acute and subacute stent thrombosis is rare, but presents itself with serious complications including high mortality and morbidity rates. Light transmittance aggregometry with specific agonists - arachidonic acid and 5-adenosin diphosphate - is still considered a standard for the assessment of platelet reactivity, besides novel methods like vasodilator-stimulated phosphoprotein phosphorylation. In our case study, we report the coincidence of high-residual platelet activity with subacute stent thrombosis despite the recommended doses of antiplatelet agents - aspirin and clopidogrel. Stent thrombosis was treated by aspiration thrombectomy, and antiplatelet treatment was modified by increasing the dose of aspirin and substituting clopidogrel with a firstgeneration thienopyridin - ticlopidin. The effect of the treatment was documented by reaching the optimal inhibition of platelet reactivity. In the 6- and 12-month follow-up, the patient presented no ischemic events.
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Evaluation of the Mechanical Properties of Gray Cast Iron Using Electrical Resistivity Measurement

86%
Bieroński M., Kuś R., Krasa O., Koza M., Książek D.
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5
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Extended Spectrum Beta Lactamase (ESBL) producing enteric bacteria from hospital wastewater, Ibadan, Nigeria

72%
Falodun O. I., Oladimeji O. S.
World News of Natural Sciences
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2019
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vol. 22
62-74
EN
This study was conducted to investigate the occurrence of antibiotic resistance, including β-lactamase and extended spectrum β-lactamase production among enteric bacteria isolated from hospital wastewater from selected hospital within Ibadan. Physico-chemical analysis of hospital wastewater samples was done, enteric bacteria were isolated and identified using convectional biochemical tests while the selection of potential ESBL-producing bacteria was carried out using disc diffusion method and ESBL detection using double synergy test. The turbidity of the wastewater samples ranged between 4.45-6.5 NTU and total suspended solids ranged between 3.4- 45.5 mg/L. While electrical conductivity was between114.25-214 µs/m, the biological oxygen demand was between 25.8-31.25 mg/L and chemical oxygen demand ranged between 41.25-45.38 mg/L. Of the 200 bacteria isolated 35(17.5%) produced ESBL; 14(40%) from the tertiary hospital and 21(60%) from private hospital out of which 85.7%, 80% and 65.7% showed resistance to sulphamethxazole/Trimetoprim, streptomycin and tetracycline respectively, while resistance to meropenem (8.6%) was low. Among the ESBL-producing isolates, K. pneumonia had the highest (15(42.8%) rate of occurrence. This study revealed a need for hospital wastewater to be properly treated before discharged into water bodies and the environment to forestall the indiscriminate discharge of wastewater harbouring ESBL-producing bacteria.
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