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Retinal calcium-binding proteins. Their function and pathology

100%

Witkowska D., Gorczyca W.

Postępy Higieny i Medycyny Doświadczalnej

1997

vol. 51

issue 1

1-22

Calcium is involved in most cellular processes through calcium-binding proteins, belonging to the EF-hand superfamily. Recently new members of this family were found in the retina of vertebrates. Functions of these proteins and their relations to some neurological diseases are reviewed. Other EF-hand proteins found in the retina are also described.

Human cord blood cells can differentiate into retinal nerve cells

86%

Koike-Kiriyama N., Adachi Y., Minamino K., Iwasaki M., Nakano K., Koike Y., Yamada H., Mukaide H., Shigematsu A., Mizokami T., Matsumura M., Ikehara S.

Acta Neurobiologiae Experimentalis

2007

vol. 67

issue 4

359-365

Retinal degeneration and dystrophy are the major causes of blindness in the developed world. It has been reported that human cord blood cells (HCBCs) can differentiate into neuron-like cells in vitro. We have recently demonstrated that bone marrow cells (BMCs) of both mice and rats can differentiate into retinal nerve cells (RNCs). In the present study, we show the differentiation capacity of HCBCs into RNCs in vivo. We transplanted lineage-negative HCBCs into the subretinal space of severe combined immunodeficiency (SCID) mice. Two weeks after the transplantation, some of the transplanted cells expressed human nestin, human MAP2, human neuron specific enolase (NSE), beta-III tubulin and also rhodopsin. These results indicate that HCBCs can differentiate into RNCs and suggest that our new strategy could be used for the regeneration of retinal nerve cells in degenerative or dystrophic diseases.

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1 Acta Neurobiologiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

1 2007

1 1997

1 Adachi Y.

1 Gorczyca W.

1 Ikehara S.

1 Iwasaki M.

1 Koike Y.

1 Koike-Kiriyama N.

1 Matsumura M.

1 Minamino K.

1 Mizokami T.

1 Mukaide H.

1 Nakano K.

1 Shigematsu A.

1 Witkowska D.

1 Yamada H.

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Retinal calcium-binding proteins. Their function and pathology

Human cord blood cells can differentiate into retinal nerve cells