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  1. 1 Biotechnologia

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  1. 1 2009

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  1. 1 Bakowska-Zywicka K.

  2. 1 Tyczewska A.

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Recycling of eucaryotic ribosomes

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Tyczewska A., Bakowska-Zywicka K.
Biotechnologia
|
2009
|
issue 1
81-85
EN
Until recently protein biosynthesis has been viewed as a process involving only three steps: initiation of translation, elongation of the nascent polypeptide chain and release of the completed unfolded polypeptide. In recent years fourth step in translation has been distinguished ? it is the recycling of the ribosome. In this process posttermination complexes termed post-TC consisting of ribosomes with deacylated tRNA(s) and mRNA are dissociated with the help of ribosome recycling factor (RRF), elongation factor G (EF-G) and initiation factor 3 (IF3) in Procaryotes. The mechanism of this final step in Eucaryotes was unknown for a long time, but the work of Pisarev et al. sheds a light on splitting 80S ribosomes and preparing them for the next cycle of translation.
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