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1

The role of the Rab proteins in intracellular transport

100%
Rapak A.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
vol. 56
|
issue 6
733-740
EN
The Rab proteins are small GTP-binding proteins and form the largest group within the Ras superfamily. Around 60 mammalian Rab proteins are known. Each Rab is localised to a specific subcellular compartment. Rabs are involved in vesicular traffic of proteins between all compartments of the cell during the exocytic and endocytic pathways. Rabs also interact with cytoskeletal elements and influence the movement of intracellular membrane vesicles and tubules. The Rab proteins are posttranslationally modified at their C-termini by addition of the 20-carbon isoprenoid, geranylgeranyl, mediated by Rab GGTase and this modification is crucial for their function. Mutations in genes encoding proteins essential for the prenylation reaction, Rab Escort Protein and Rab geranylgeranyl transferase, lead to genetic diseases called Choroideremia and Hermansky-Pudlak syndrome.
2

Role of the adaptins, dynamin-like GTP-ases and Rab proteins in metabolic disorders and various infections

70%
Kierczak M., Surmacz L., Wiejak J., Wyroba E.
Postępy Higieny i Medycyny Doświadczalnej
|
2003
|
vol. 57
|
issue 6
727-737
EN
Numerous metabolic and genetic diseases are due to mutations in adaptins, dynamin-like GTP-ases or disorders in trafficking machinery mediated by Rab proteins. A great number of pathogenes including viruses (HIV, SIV), bacteria and protozoa use various elements of endocytic/trafficking machinery to get into the host cells and to make their infection successful. Their different strategies are discussed.
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