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RP-HPLC determination of lipophilicity in series of quinoline derivatives

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Musiol R., Jampilek J., Podeszwa B., Finster J., Tabak D., Dohnal J., Polanski J.

Open Chemistry

2009

vol. 7

issue 3

586-597

In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure of the studied compounds. [...]

Palladium-catalyzed amination of quinaldine-5-triflate

100%

Fekete M., Töröncsi M., Novak L.

Open Chemistry

2008

vol. 6

issue 1

33-37

Palladium-catalyzed amination reactions of quinoline triflate and the effect of a Pd catalyst, its ligands, solvents, bases, and temperature were studied. This method facilitated an easier pathway for the preparation of aminoquinoline derivatives as potential precursors of new serotoninerg agents. [...]

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2 Open Chemistry

1 2009

1 2008

1 Dohnal J.

1 Fekete M.

1 Finster J.

1 Jampilek J.

1 Musiol R.

1 Novak L.

1 Podeszwa B.

1 Polanski J.

1 Tabak D.

1 Töröncsi M.

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RP-HPLC determination of lipophilicity in series of quinoline derivatives

Palladium-catalyzed amination of quinaldine-5-triflate