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Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

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Souza G., Rodrigues M., Fernandes L., Silva P., Ruggiero R., Pereira-Maia E., Guerra W.
Open Chemistry
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2013
|
vol. 11
|
issue 2
290-294
EN
New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin. [...]
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