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The paper presents an application of phosphatidylcholine 45% (PC 45) and polyvinylpyrrolidone (PVP) in formulations of magnesium salts such as Mg(VitB6) and Mg(VitB6Arg) prepared by solid dispersion (SD) techniques. The evaluation of influence of the selected carriers on some physicochemical properties of solid dispersions and on the absorption process of Mg +2 ions in vitro were made. An infrared (IR) spectra study suggested creation of a hydrogen bond between the carriers and the examined magnesium salts. The results of the following thermal analysis: differential thermal analysis (DTA), thermogravimetry (TG), and differential scanning calorimetry (DSC) showed that application of PVP into SD lower the temperature of the decomposition process. However, in the case of PC 45 into SD the characteristic thermal effects of higher temperatures were observed. Moreover, values of the enthalpy SD of decomposition process were decreased. The results of these studies on absorption process of Mg2+ ions in vitro showed the positive influence of the applied carriers on the partition coefficient values (log P) in the examined formulation.
EN
Abstract The interaction between Mg2+ and a phosphatidylcholine (lecithin, L) monolayer at the air/water interface was investigated. Surface tension measurements (Langmuir method) of phosphatidylcholine monolayers as a function of Mg2+ concentration were carried out at 22°C using a Teflon trough and a Nima 9000 tensiometer. Interactions between phosphatidylcholine and Mg2+ result in significant deviations from additivity. An equilibrium theory was developed to obtain the stability constants and areas occupied by one molecule of LMg+ and L2Mg. The stability constants were K 1 = 9.95×102 m2 mol−1 and K 2 = 3.87×104 m2 mol−1. The area occupied by LMg+ is 77 Å2 molecule−1, while that occupied by L2Mg is 109 Å2 molecule−1. The Gibbs free energies of complexation for LMg+ and L2Mg are −16.91 ± 0.51 and −25.88 ± 0.76 kJ mol−1. Graphical abstract [...]
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