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Inadvertent epidural infusion of paracetamol in an elderly patient

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Dehne M.
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EN
A 76 year old patient underwent a laparoscopic rectal resection performed under thoracic epidural anaesthesia and general anaesthesia. He was inadvertently given 1 g of paracetamol epidural and reported a position-independent holocephalic headache one day later. A severe nausea and vomiting lead to a gastrointestinal bleeding. The last neurological examination after 3 months revealed no nausea, no headaches and no sensory disturbances.
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Nephroprotective role of Potentilla reptans L. aqueous extract on paracetamol - induced kidney nephrotoxicity in male mice

88%
Muthulingam M., Prabhahar C., Senthilmurugan S., Pugazhendy K., Vijayan P., Baranitharan M.
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vol. 39
76-85
EN
Nephroprotective effects (NPE) of simple Potentilla reptans - aqueous leaf extract (Pr-ALE) leaves on Paracetamol induced kidney poisonousness in wistar rats. Adult male wistar rats (weight range (WR): 200-220g) were divided into 6 groups (n=6). Paracetamol (PA) and Silymarin (SY) stayed managed intraperitoneally arranged the 5th day to rats in all groups but the normal control. Furthermore, a significant nephroprotective (NP) of the aqueous leaf extract (ALE) and oral dose of PA and SY. Pr-ALE did not mortality or significant changes in the body weight. Progression of nephrotoxicity (NT) induced by PA in rats was interfered by Pr-ALE managed, and these effects were correspond to those managed with SY. This is the first record on NPE of Pr against PA-induced NT.
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