By means of the radioimmunologic method changes of concentration of 6-keto prostaglandin F1alpha(PGF1alpha) - the stable metabolite of prostacyclin in the rat brain have been evaluated during 5-min clinical death and up to 2 hrs after resuscitation Ischemia did not produce significant changes of 6-keto-PGF1 in the and 7-fold control values. Later the concentration of 6-keto-PGF1alpha in the brain decreased reaching in 30 min a 3-fold the control level, and in 60 and 120 min after resuscitation control values. The reasons of unsuccessful therapy of ischemic stroke with prostacyclin are discussed.
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.