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1

Polymorphonuclear leukocytes as a potential source of oxygen free radials in myocardial infarction

100%
Wysocka J.
Postępy Higieny i Medycyny Doświadczalnej
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1995
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vol. 49
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issue 2
297-304
2

Lack of relationship between serum content of MBL, sCD14, anti-PPD and anti-Hsp65 IgG, and ingestion of Mycobacterium bovis BCG bacilli by phagocytes

100%
Paziak-Domanska B., Bonar A., Kowalewicz-Kulbat M., Klink M., Kowalski M., Karhukorpi J., Karttunen R., Jurkiewicz M., Rozalska B., Rudnicka W.
Archivum Immunologiae et Therapiae Experimentalis
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2002
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vol. 50
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issue 5
337-344
EN
Prophylactic vaccination against tuberculosis (TB) with a live attenuated strain of Mycobacterium bovis Bacille Calmett?e-Gerin (BCG) has been used worldwide. However, TB remains one of the most significant diseases of humans and animals. Better understanding of the mechanisms of human immunity to mycobacteria is essential for development of new vaccines and estimation of their efficacy. In this study we determined the levels of known humoral mediators of mycobacterial phagocytosis - mannose binding lectin (MBL), soluble CD14 (sCD14), antibodies of IgG class against mycobacterial purified protein derivative (PPD) and mycobacterial Hsp65 antigen, in the sera from healthy young volunteers vaccinated with BCG and presenting positive and negative Mantoux responses to PPD. Than we asked a question as to whether macrophages and polymorphonuclear leukocytes (PMNs) from the individuals with positive (TT(+)) and negative (TT(-)) tuberculin tests differ by the ability to ingest mycobacteria. Also we were looking for a relation between the intensity of mycobacterial ingestion by phagocytes in the medium with autologous sera containing different concentration of MBL, sCD14 andf anti-mycobacterial IgG. We found no significant differences between the investigated parameters for TT(+) and TT(-) volunteers. Our result suggest that ability of macrophages and PMNs to ingest mycobacteria depends on an individual intrinsic capacity of phagocytes.
3

Specific allergen induced motility of peripheral blood mononuclear cells and polymorphonuclear leukocytes in insect sting allergy

88%
Zak-Nejmark T., Malolepszy J., Jutel M., Nittner-Marszalska M.
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vol. 40
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issue 2
107-111
EN
The motility of perpheral blood mononuclear cells (MNC) and polymorphoxnuclear (PMN) leukocytes form normal and bee venom allergic subjects was investigated by a modified Boyden micropore filter method. The study comprised MNC locomotion in bee venom and gradients and PMN locomotion in bee venom and fMLP gradients. We demonstrated statistically significant increase in MNC and PMN motility towards bee venom in allergic patients group. This effect disappeared after the preincubation of MNC with anti-human IgE antiboidies. We observed no such effect in PMN leukocytes. Increased MNC motility in histamine gradient was observed only in control subjects group. Similarily significant increase in PMN locomotion towards fMLP was found in both allergic and control subjects. The results here demonstrated suggest that a specific allergen might be a chemoattractant for peripheral blood MNC and PMN leukocytes from atopics and could be capable to induce non-infectious inflammatory reactions as a result of its interaction with these sensitive cells.
4

The effect of Chlamydia trachomatis infection of the prostate gland on the concentration of citric acid

88%
Zdrodowska-Stefanow B., Ostaszewska-Puchalska I., Badyda J., Galewska Z.
Archivum Immunologiae et Therapiae Experimentalis
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2006
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vol. 54
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issue 1
69-73
EN
Introduction: The objective of the study was to assess the relationship between Chlamydia trachomatis (C.t.) infection of the prostate and the concentration of citric acid. Materials and Methods: The study involved 60 patients with chronic prostatitis (NIH III). Urethral swabs and expressed prostatic secretions (EPS) were collected for analysis. The urethral swabs were tested for PMNs and the presence of Neisseria gonorrhoeae and C.t., while the EPS were analyzed to determine PMN count, C.t., and citric acid concentration. The DFA or LCR method was used for C.t. diagnosis. The concentration of citric acid was measured using the UV method. Results: Inflammation of the prostate (PMNs 10/field) was diagnosed in 58.3% of the patients. C.t. infection was found in 20%, including 8.3% with only the urethra affected and 10% with only the prostate. One patient had both the urethra and the prostate infected. A reduction in the concentration of citric acid in EPS was observed in 56.7% of the men. In 88.2% of the patients, reduced citric acid concentration was accompanied by an elevated PMN count in the EPS. All patients with C.t. infection of the prostate showed a reduced concentration of citric acid. In five patients with urethral infection, lack of a decrease in this parameter was noted in one. In all the patients with chlamydial infection, irrespective of localization, a high PMN count was observed in the EPS.Determination of the concentration of citric acid in the prostatic fluid is a good indicator of prostatitis. C.t. infection of the prostate gland is accompanied by a decrease in the concentration of citric acid.
5

Effect of exogenous opioid peptides on TNF--induced human neutrophil apoptosis in vitro

75%
Sulowska Z., Majewska E., Tchorzewski H., Klink M.
Archivum Immunologiae et Therapiae Experimentalis
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2003
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vol. 51
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issue 4
267-272
EN
Polymorphonuclear leukocytes (neutrophils) apoptosis is an important mechanism regulating the life span and some functions of neutrophils at inflamed sites. The opioid peptides are present in the peripheral circulation and their concentrations rapidly increase as the result of stress and inflammation. The effect of opioid peptides such as met-enkephalin (M-ENK) and beta-endorphin (beta-END) on tumor necrosis factor alpha (TNF-alpha)-induced apoptosis in human neutrophils in vitro was investigated. Neutrophils isolated from peripheral blood were cultured in the absence or presence of 106-1010 M of opioid peptides for 8, 12 and 18 hours. Features of apoptotic neutrophils were measured by flow cytometric method based on analysis of apoptotic nuclei (DNA content). We found that M-ENK and beta-END enhanced both non-induced and TNF-alpha-induced neutrophil apoptosis in vitro in a dose-dependent manner. The effect of opioid peptides on modulation of neutrophil apoptosis was not reversed by opioid-receptor antagonist naloxone. The results suggest that M-ENK and beta-END can regulate neutrophil life span via apoptosis and in this way may participate in resolution of inflammation.
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