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Polyamines and their role in tumour growth

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Godlewska J., Peczynska-Czoch W.
Postępy Higieny i Medycyny Doświadczalnej
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2002
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vol. 56
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issue 6
757-777
EN
The polyamines - putrescine, spermidine and spermine - are normal constituents of prokariotic and eukariotic cells. These small polycationic, aliphatic compounds are essential for normal cell proliferation. Cells cease to proliferate, when they are depleted of their polyamines, but resume a normal growth rate after supplementation with these compounds. Because of the sustained increase in polyamine biosynthesis in preneoplastic and neoplastic tissues, a great deal of interest has been given to the polyamine biosynthesis, network and uptake systems as a target in antineoplastic strategies.
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