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Plasma levels of alphabeta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease

100%

Sobow T., Flirski M., Kloszewska I., Liberski P. P.

Acta Neurobiologiae Experimentalis

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2005

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vol. 65

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issue 2

117-124

EN

Plasma AlphaBeta levels have been examined in sporadic Alzheimer's disease yielding conflicting results; both no difference and an increase in plasma concentrations of A1-42 and A1-40 in sporadic cases of AD as compared to controls have been reported. Elevated plasma A1-42 levels may be detected several years before the onset of symptoms (in mild cognitive impairment stadium). Levels of AlphaBeta140 and AlphaBeta142 were measured in plasma from 54 patients with AD, 39 subjects with MCI and 35 controls using a commercially available ELISA. Mean plasma AlphaBeta142 levels were significantly higher in MCI as compared to both AD (P<0.001) and control subjects (P<0.001), while AlphaBeta140 did not differ between the groups. No correlations were observed between A levels and age, MMSE scores or gender. According to ROC curve analysis the maximum accuracy in discriminating MCI versus both controls and AD subjects has been achieved using a cut-off value of 3.8.

2

Plasma Abeta levels as predictors of response to rivastigmine treatment in Alzheimer's disease

100%

Sobow T., Flirski M., Liberski P., Kloszewska I.

Acta Neurobiologiae Experimentalis

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2007

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vol. 67

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issue 2

131-139

EN

Cholinesterase inhibitors are currently the mainstream of symptomatic treatment of patients with Alzheimer's disease. The response to treatment with cholinesterase inhibitors is clinically difficult to predict. Several demographic, clinical and biological variables have been proposed as pretreatment predictors of long-term therapy efficacy. In this paper, consistently with previous reports, we confirm that higher initial disease severity and faster progression of cognitive impairment increase the chance of a clinically meaningful response to cholinesterase inhibitor therapy in a carefully selected population of patients with Alzheimer's disease. Moreover, for the first time we demonstrate the association between the increase in the concentration of plasma Abeta(1-42) peptide after 2 weeks of treatment with an initial dose of rivastigmine and the likelihood of a positive response to treatment after 6 months. A change in plasma Abeta(1-42) level might constitute a novel biochemical predictor of rivastigmine treatment efficacy in Alzheimer's disease.

3

Investigation of the causes underlying incisor overgrowth in the chinchilla using plasma concentrations of selected minerals

75%

Muszczynski Z., Sulik M., Ogonski T., Antoszek J.

Folia Biologica

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2010

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vol. 58

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issue 1-2

107-111

EN

The aim of the study was to identify the causes underlying overgrowth of incisors in chinchillas through an analysis of selected plasma electrolyte concentrations, with particular consideration of minerals involved in the formation of osseous tissue, i.e. Ca,Mg, and P. The analysis involved 40 female standard chinchillasmanaged in a commercial farmsystem, aged 2 to 4 years, divided into two groups of 20 individuals each: D . chinchillas with incisor overgrowth and C . controls with normal dentition. Concentrations of Ca, Mg, and P were measured in blood plasma. The analysis was carried out using ICP OES (inductively coupled plasma optical emission spectrometry) by means of the Optima 2000 DV instrument (Perkin Elmer). The resulting data were analysed statistically using one-way ANOVA with Duncan.s range test. The results show that abnormal metabolism of dental tissue minerals, especially Ca and P, cannot be excluded as the cause of tooth overgrowth in chinchilla.

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Plasma levels of alphabeta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease

Plasma Abeta levels as predictors of response to rivastigmine treatment in Alzheimer's disease

Investigation of the causes underlying incisor overgrowth in the chinchilla using plasma concentrations of selected minerals