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The presence of histamine and tele-methylhistamine in the pineal gland of chick

100%
Zawilska J. B., Woldan-Tambor A., Sek B., Orszulak-Michalak D., Mackova M., Nowak J. Z.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 3
691-695
EN
The levels of histamine (HA) and tele-methylhistamine (t-MeHA) in the pineal gland of chick were measured by RIA and two time points, i.e. at the end of the light (L) phase and in the middle of the dark (D) phase of 12h :12h L:D cycle.The chick pineal gland showed high HA levels.The t-MeHA content of chick pineal gland was about 20-times lower than HA levelAn aminoacid precursor of HA, L-histidine given to chicks during L or D significantly increased both HA and t-MeHA content of pineal gland.The L-histidine-evoked elevations in HA level were 2-4 times higher than changes in t-MeHA content.Enzymatic study showed the presence of chick pineal gland of a moderate activity of L-histidine decarboxylase, and well expressed activity of HA-methyltransferase, HA synthetizing and inactivating enzyme, respectively, which suggest that both HA and t-MeHA may be produced within the gland.It is suggested that the metabolic dynamics of the pineal HA may be higher during lighthours than darkhours of the daily light:dark illumination cycle.
2

The role of in human physiology and pathology.I. of .Involvement of melatonin in reproductive physiology.Melatonin and hypothalamic-pituitary-adrenal cortex axis

100%
Slowinska-Klecka D., Lewinski A.
Postępy Higieny i Medycyny Doświadczalnej
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1993
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vol. 47
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issue 3
209-228
EN
This paper summarizes the recent knowledge on the role of in humans. The first part of the present review considers the following aspects: of , in , melatonin influence on , changes of melatonin blood concentration during the and , and the influence of on . Current views on the relationship between melatonin and the hypothalamo-pituitary-adrenal cortex axis, as well as on changes of during , and are also discussed.
3
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Melatonin as a chemical indicator of environmental light-dark cycle

75%
Zawilska J. B.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 3
757-767
EN
Melatonin is an evolutionary highly conserved molecule that plays an important role in conveying the clock and calender information to all living organisms, including man.Melatonin is synthesized in the rhythmic fashion, primarily by the pineal gland, and to a lesser degree, by extrapineal tissues - namely the retina, the Harderian gland, and the gastrointestinal tract.The rhythm of the hormone production, with maximal levels occuring at night in darkness, is generated by an endogenous circadian clock(s) and is synchronized with the photoperiodic environment to which animals are exposed.This brief outline surveys data on the regulation of rhythmic melatonin biosynthesis by a circadian pacemaker and light.Additionally, possible applications of this chronobiotic compound in agriculture and in medicine in the treatment of circadian rhythm sleep disorders are discussed.
4

Time and reproductive phase-dependent effects of exogenous melatonin on the pineal gland and ovary of a nocturnal bird, the indian spotted owlet, Athene brama

75%
Guchhait P., Haldar C.
Folia Biologica
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2000
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vol. 48
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issue 3-4
91-96
EN
In a tropical nocturnal bird, the Indian spotted owlet, Athene brama, the intraperitonial injection of an identical amount (20mg/ 100 g b. wt/ day) of exogenous melatonin (MEL) for 15 consecutive days increased the pineal weight and plasma MEL level in sexually active birds while it decreased them in inactive birds more potently when injected in the evening (18.30-19.30 h) rather than the morning (0500-0600 h). On the other hand, more efficiently than the morning hour treatment, the evening hour MEL injection decreased the ovary weight and plasma estradiol and progesterone levels both in sexually active and inactive birds, but more potently in active than inactive birds. Thus, the exogenous MEL showed the time and reproductive phase dependent effects on the pineal gland and the ovary of this nocturnal bird.
5

The role of melatonin in human physiology and pathology.II.Involvement of melatonin in pathogenesis of affective and chronobiological disorders, Melatonin and aging

75%
Slowinska-Klencka D., Lewinski A.
Postępy Higieny i Medycyny Doświadczalnej
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1993
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vol. 47
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issue 4
267-276
EN
In the second part of this review the role of in of and is discussed. Current views on melatonin involvement in aging are presented. Clinical experiments on the possible usefulness of melatonin in treatment of various types of cancers and hypothetical mechanisms of oncostatic influence of melatonin are also summarized.
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