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Effects of repeated systemic penicillin injections on nonconvulsive and convulsive epileptic seizures in the rat

100%
Stankiewicz J., Stankiewicz M., Wiaderna-Stepien D., Gralewicz S.
Acta Neurobiologiae Experimentalis
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1995
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vol. 55
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issue 4
281-287
2
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The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy

100%
Kozan R., Ayyildiz M., Yildirim M., Agar E.
Acta Neurobiologiae Experimentalis
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2009
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vol. 69
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issue 2
177-188
EN
The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats received a daily dose of 3 g/kg or 9.0 g/kg of 30% ethanol solution for 3 days. Thirty minutes after penicillin injection (500 units, i.c.), the most effective dose of alpha-tocopherol (500 mg/kg) was administered intramuscularly (i.m.). Acute administration of ethanol, in a dose of 3 g/ kg, did not change either frequency or amplitude of penicillin-induced epileptiform activity, while dose of 9 g/kg ethanol significantly decreased the mean frequency of penicillin-induced epileptiform ECoG activity in the ethanol-treated group. Ethanol (9 g/kg) withdrawal also caused an increase in the amplitude of epileptiform ECoG activity in the withdrawal group. The results suggest that acute administration of high dose ethanol (9 g/kg) and alpha-tocopherol have some limited anticonvulsive effects in penicillin-induced epileptiform activity in rats.
3
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The influence of repeated systemic penicillin injections at subconvulsive doses on spontaneous Spike-Wave Discharges in the rat

88%
Stankiewicz J., Gralewicz S.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 3
673-681
EN
Changes in nonconvulsive spontaneous epileptic activity- Spike-Wave Discharges (SWD) - induced by repeated intraperitoneal (i.P.) administration of crystaline panicillin (CP) at subconvulsive doses were evaluated in imp-DAK rats.Three groups received tan daily i.p.injections of PC at doses of 750.000, 500.000 and 250.000 IU/kg b.w..For comparison, another classic convulsant, penetylenetrazol (PTZ) was applied in the same way to another group.PTZ was also given in CNS excitability.Repeated PC injections resulted in a progressive increase in the basal level of the spontaneous SWD activity and in increase in the SWD response to PC, which was statistically significant in the case of the dose 750.000 IU/kg b.w..Moreover, in all rats given PC the response to PTZ (increase in SWD activity) was reduced.The results obtained in this and previous experiment suggest that in the rat CNS develop which prevent to convulsive effect of Pc but promote the occurence of the spontaneous nonconvulsive SWD activity.
4
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Anticonvulsive effects of nimodipine on penicillin-induced epileptiform activity

88%
Bagirici F., Bostanci O.
Acta Neurobiologiae Experimentalis
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2006
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vol. 66
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issue 2
123-128
EN
The common features of all types of epilepsy are synchronized and uncontrolled discharges of nerve cell assemblies. It is believed that calcium ions play an important role in the generation of epileptic activity. Excessive calcium influx into neurons is the first step toward a seizure. The aim of the present study is to investigate whether the calcium channel blocker nimodipine has anticonvulsive effects. The left cerebral cortex was exposed by craniotomy in anaesthetized rats. An epileptic focus was produced by injection of penicillin G potassium (500 units) into the somatomotor cortex. After the epileptiform activity reached maximum frequency and amplitude; nimodipine was injected into the same area. Application of nimodipine caused an inhibition in the electrocorticograms (ECoG). Solvent alone did not affect the epileptiform activity. The results of this study indicate that nimodipine may have anticonvulsant effects.
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