The article contains a survay of the recent papers on the which regulate the process of - PAI-1 and PAI-2. Both of them belong to serine family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1 : 1 with them. PAI-1, secreted mainly by and , is the main plasmic inhibitor of plasminogen activation. PAI-2, originated essentially from , appears in during .
The paper deals with the current state of knowledge on . The , multiple biosynthesis pathways, possible mechanisms of action, and participation of lipoxins in are characterised.
The data on the structure and the role of lipoprotein (a) were presented. It posses plasminogene and lipoproteins elements in its structure. Up to now it is not well known the physiological role of lipoprotein (a). There are many proofs in the literature that lipoprotein (a) is an independent coronary risk factor. It is also known as an acute phase protein.
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