Search results

Search:
in the keywords: Neopterin

Sort By:

Limit search:

Serum neopterin in workers exposed to inorganic dust containing free crystalline silicon dioxide

100%

Prakova G., Gidikova P., Slavov E., Sandeva G., Stanilova S.

Open Medicine

2009

vol. 4

issue 1

104-109

The study was conducted among 92 male workers, divided into two groups depending on workplace and level of inorganic dust containing free crystalline SiO2 in the work environment, and 43 healthy workers without exposure to dust aerosols. The measured inhalable and respirable dust concentrations, as well as the concentration of free crystalline silica (FCS) in the respirable fraction were different for the two groups, but the percentage of free crystalline silica in the respirable fraction was almost identical. Significantly higher neopterin levels were found in workers exposed to dust, compared to the control group: 12.72 nmol/L and 6.32 nmol/L respectively (p<0.05). No significant difference was found between serum neopterin levels in both groups of the exposed workers. Among the groups with different length of service, a statistically higher neopterin level was evident only in the workers with length of service less than 10 years (p<0.05). The correlation analysis did not find a significant dependence of neopterin levels on the age of the studied workers or on the duration of smoking in packet years. The difference between neopterin levels in smokers and non-smokers was nonsignificant. The results obtained show that increased neopterin levels in the exposed workers are not influenced by individual features, duration and level of exposure to inorganic dust, but mostly by the presence of FCS in the respirable fraction.

Serum neopterin as a prognostic indicator in patients with breast carcinoma

80%

Kocer B., Turan U., Surmeli S., Altun B., Aksaray S., Yilmaz O., Cengiz O.

Open Medicine

2010

vol. 5

issue 5

544-550

Neopterin is a useful indicator of the activation state of the cellular immune system, and an elevated level predicts prognosis in different types of tumors. The aim of this study was to evaluate serum neopterin levels if it is viable predictor for prognosis in breast carcinoma patients. Serum neopterin was investigated in 56 breast carcinoma patients, 16 patients with benign breast lesions and 16 healthy women as controls. Neopterin was measured by ELISA (Enzyme-linked immunosorbent assay). The clinicopathological parameters were determined by reviewing both medical charts and pathological records. All patients had been followed-up until September 2009 or death.The mean serum neopterin concentrations were 8.5 ± 5.2 nmol/L in patients with breast carcinoma, 6.5±3.1 nmol/L in patients with benign breast lesion and 8.1 ± 1.9 nmol/L in healthy volunteers (p>0.05). Elevated neopterin levels were significantly correlated with age, elevated serum CRP level, advanced stage and presence of the distant metastases (p<0.05). Overall survival was significantly shorter in patients with a serum neopterin level >10 nmol/L than patients with neopterin <10 nmol/L level (56 months vs. 76 months, p=0.011). Increased preoperative serum neopterin concentrations are associated with a poor prognosis in patients with breast carcinoma.

Refine search results

2 Open Medicine

1 2010

1 2009

1 Aksaray S.

1 Altun B.

1 Cengiz O.

1 Gidikova P.

1 Kocer B.

1 Prakova G.

1 Sandeva G.

1 Slavov E.

1 Stanilova S.

1 Surmeli S.

1 Turan U.

1 Yilmaz O.

Search results

Serum neopterin in workers exposed to inorganic dust containing free crystalline silicon dioxide

Serum neopterin as a prognostic indicator in patients with breast carcinoma