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Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry

100%

Kowcun K., Frańska M., Frański R.

Open Chemistry

2012

vol. 10

issue 2

320-326

The solutions containing one of the copper salts (CuCl2, Cu(ClO4)2, Cu(NO3)2, and CuSO4) and one of the non-steroidal anti-inflammatory drugs (NSAIDs, ibuprofen, ketoprofen or naproxen) were analyzed by electrospray ionization mass spectrometry. Three of the salts, namely CuCl2, Cu(ClO4)2 and Cu(NO3)2, yielded binuclear complexes of drug:metal stoichiometry 1:2. Existence of the complexes of such stoichiometry has not been earlier observed. For copper(II) chloride the complexes (ions of the type [M-HCOOH+Cu2Cl]+ and [M+Cu2Cl]+, M stands for the drug molecule) were formed in the gas phase. When copper(II) perchlorate or copper(II) nitrate was used, the observed binuclear copper complexes (ions of the type [M-H+Cu2(ClO4)2+CH3OH]+, [M-H+Cu2(ClO4)2]+ and [M-H+Cu2(NO3)2+CH3OH]+, [M-H+Cu2(NO3)2]+) were observed at low cone voltage, thus these complexes must have already existed in the solution analysed. Therefore, such complexes may also exist under physiological conditions. [...]

MCM-41 silica as a host material for controlled drug delivery systems

100%

Krasucka P., Goworek J.

Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

2015

vol. 70

issue 2

The adsorption and release of Naproxen as a model drug was studied. The MCM-41 silica was chosen as a model adsorbent. The synthesis of mesoporous silica was performed by template method using cetyltrimethylammonium bromide CTAB as a pore directing agent. Synthesized MCM-41 material of high quality was used as a carrier for Naproxen. The loading procedure was performed at normal conditions and under vacuum. The release of drug was measured for differentially prepared samples. The results for MCM-41 are compared to those measured for silica gel for column chromatography Si-100 containing substantially larger pores. The results are discussed taking into account the penetration of pore system by loading solution as well as in terms of the proportion of dimensions of Naproxen molecule and pore dimensions of MCM-41.

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1 Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

1 Open Chemistry

1 2015

1 2012

1 Frańska M.

1 Frański R.

1 Goworek J.

1 Kowcun K.

1 Krasucka P.

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Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry

MCM-41 silica as a host material for controlled drug delivery systems