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  1. 1 Biotechnologia

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  1. 1 1994

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  1. 1 Koziolkiewicz M.

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Stability of antisense oligonucleotides - the possibillities of their enzymatic digestion

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Koziolkiewicz M.
Biotechnologia
|
1994
|
issue 4
50-54
EN
Nucleotic enzymes (5- and 3-nucleases, exo and endonucleases) can degrede short unmodified oligonucleotides applied as potential antisense agents. Better stability of oligonucleotides against nucleolytic enzymes can be achieved by chemical modification of internucleotide bonds.Stability of the phosphorothioate, phosphoroditioate and methylphosphonate analogues of oligonucleotides against nuclease P1,3-exonuclease, snake venom phosphodiesterase and other nucleases is discussed
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