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  1. 1 Acta Biochimica Polonica

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  1. 1 2012

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  1. 1 Siomek A.

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NF-κB signaling pathway and free radical impact

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Siomek A.
|
2012
|
vol. 59
|
issue 3
323-331
EN
The activation of NF-κB transcription factor is critical for a wide range of processes such as immunity, inflammation, cell development, growth and survival. It is activated by a variety of stimuli including cytokines, ionizing radiation and oxidative stress. Redox modulations of NF-κB pathway have been widely demonstrated. Studies carried out during last years have advanced our knowledge about possible connections between NF-κB pathway and the impact of free radicals. This review is an endeavor to gather recent results focused on this issue, although an important question, whether oxidative stress plays a physiological role in NF-κB activation, seems to be still unanswered.
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