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Neurotoxin induced modification of a cockroach central nervous system bioelectrical activity

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Stankiewicz M., Panek I., Grajpel B., Tegowska E., Kadziela W., Pelhate M.

Postępy Higieny i Medycyny Doświadczalnej

2000

vol. 54

issue 3

371-379

Natural neurotoxins are promising molecules in the actual search for the development of alternative pest management since chemical insecticides pose unacceptable risks to the environment and to health. The aim of the article is to describe the application of two electrophysiological methods (double-oil-gap technique used on cockroach isolated giant axon and microelectrode technique used on cockroach neurosecretory DUM cells in situ) to study neurotoxin effects on insect nervous system function.

NG2 expressing cells in hippocampal cultures survive neurotoxic insult and retain the ability to divide

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Dzwonek K.

Acta Neurobiologiae Experimentalis

2005

vol. 65

issue 2

173-176

It has been recently proposed that NG2 proteoglycan expressing cells may stand for a unique class of glia in adult CNS referred to as oligodendrocyte progenitor cells (OPCs). These NG2 positive cells can give rise to mature oligodendrocytes, however a large number of them persists in immature stage throughout a lifetime and responds to various types of injury. In order to investigate OPCs reactivity in vitro, a model of trimethyltin evoked neurodegeneration was used. The results demonstrate that NG2 expressing cells survive treatment with the neurotoxin in a concentration that injures most of neurons in the culture. Moreover, progenitors change their morphology when treated with trimethyltin, upregulate the NG2 proteoglycan expression and retain the ability to divide.

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1 Acta Neurobiologiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

1 2005

1 2000

1 Dzwonek K.

1 Grajpel B.

1 Kadziela W.

1 Panek I.

1 Pelhate M.

1 Stankiewicz M.

1 Tegowska E.

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Neurotoxin induced modification of a cockroach central nervous system bioelectrical activity

NG2 expressing cells in hippocampal cultures survive neurotoxic insult and retain the ability to divide